PLXNB1 and L1CAM

Number of citations: 0 (PubMedID 25315821)
Data Source: BioGRID (two hybrid)

		PLXNB1	L1CAM
Name		plexin B1	L1 cell adhesion molecule
Structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Postsynaptic Membrane Glutamatergic Synapse	Plasma Membrane Focal Adhesion Cell Surface Membrane Axon Dendrite Growth Cone Extracellular Matrix Cell Projection Neuronal Cell Body Axonal Growth Cone
	Molecular Function	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Semaphorin-plexin Signaling Pathway Inhibitory Synapse Assembly	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Cell Differentiation Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Axon Development
Pathways		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RHOD GTPase cycle	Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1
Drugs		None	Ethanol
Diseases		None	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum Hereditary spastic paraplegia (SPG)
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 31152163 ) Inflammatory bowel disease ( 28067908 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 )	No GWAS studies recorded
Interacting Genes		15 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MECOM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4	24 interacting genes: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2
Entrez ID		5364	3897
HPRD ID		03032	02394
Ensembl ID		ENSG00000164050	ENSG00000198910
Uniprot IDs		O43157	P32004
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W 7VF3 7VG7 8B3K	8AFO 8AFP
GO Terms Enriched among Interactors		Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Chemotaxis Locomotion Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Hypothalamus Cell Migration Neuron Projection Development Neural Crest Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Mesenchymal Cell Migration Anatomical Structure Arrangement Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Rho Protein Signal Transduction Motor Neuron Axon Guidance Cellular Developmental Process Ventral Trunk Neural Crest Cell Migration Small GTPase-mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Plasma Membrane Bounded Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Ameboidal-type Cell Migration Trigeminal Ganglion Development Cell Migration Positive Regulation Of Cell Migration Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Negative Chemotaxis Neuron Migration Positive Regulation Of Locomotion Cranial Ganglion Development Trunk Neural Crest Cell Migration Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Migration Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Regulation Of Cell Motility Regulation Of Actin Filament-based Process Cell Motility Regulation Of Locomotion	Postsynaptic Membrane Semaphorin Receptor Complex Semaphorin Receptor Activity Cell Projection Organization Regulation Of Cellular Component Organization Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Hypothalamus Cell Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Signal Transduction Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Positive Regulation Of Protein Localization To Endosome Glutamatergic Synapse Cell Adhesion Focal Adhesion Cell Migration Neuron Migration Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Early Endosome To Late Endosome Transport Regulation Of Protein Metabolic Process Neuron Projection Development Regulation Of Transport Regulation Of Cell Migration ATPase Binding Regulation Of Cell Motility Ventral Trunk Neural Crest Cell Migration Apical Part Of Cell Cell Motility Regulation Of Cell Communication Regulation Of Locomotion Cell Adhesion Molecule Binding Microvillus Membrane Gland Morphogenesis Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Intracellular Signal Transduction Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Axon Guidance Regulation Of Anatomical Structure Morphogenesis Basolateral Plasma Membrane Membrane To Membrane Docking