PLXNB1 and SEMA4D

Number of citations of the paper that reports this interaction (PubMedID 11937491)
31

Data Source:
HPRD (in vitro, in vivo)

		PLXNB1	SEMA4D
Description		plexin B1	semaphorin 4D
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Postsynaptic Membrane Glutamatergic Synapse	Semaphorin Receptor Complex Extracellular Space Nucleoplasm Centrosome Plasma Membrane Membrane Ciliary Basal Body Postsynaptic Membrane GABA-ergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Semaphorin Receptor Binding Signaling Receptor Activity Neuropilin Binding Identical Protein Binding Chemorepellent Activity Receptor Ligand Activity
	Biological Process	Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Semaphorin-plexin Signaling Pathway Inhibitory Synapse Assembly	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Nervous System Development Axonogenesis Axon Guidance Regulation Of Cell Shape Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synapse Assembly Bone Trabecula Morphogenesis Regulation Of Biological Quality Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Inhibitory Synapse Assembly
Pathways		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RHOD GTPase cycle	Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Other semaphorin interactions
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576) Body mass index ( 28296344) Brain morphology (MOSTest) ( 32665545) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		15 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MECOM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4	6 interacting genes: CD72 CRK DSCAM LINC00839 PLXNB1 PTPRC
Entrez ID		5364	10507
HPRD ID		03032	03520
Ensembl ID		ENSG00000164050	ENSG00000187764
Uniprot IDs		O43157	E9PFD9 Q92854
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W 7VF3 7VG7 8B3K	1OLZ 3OL2
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Chemotaxis Locomotion Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Hypothalamus Cell Migration Neuron Projection Development Neural Crest Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Mesenchymal Cell Migration Anatomical Structure Arrangement Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Rho Protein Signal Transduction Motor Neuron Axon Guidance Cellular Developmental Process Ventral Trunk Neural Crest Cell Migration Small GTPase-mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Plasma Membrane Bounded Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Ameboidal-type Cell Migration Trigeminal Ganglion Development Cell Migration Positive Regulation Of Cell Migration Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Negative Chemotaxis Neuron Migration Positive Regulation Of Locomotion Cranial Ganglion Development Trunk Neural Crest Cell Migration Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Migration Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Regulation Of Cell Motility Regulation Of Actin Filament-based Process Cell Motility Regulation Of Locomotion	Regulation Of Cell Adhesion Protein Tyrosine Kinase Binding Signaling Receptor Binding Regulation Of Locomotion Regulation Of Neuron Projection Development Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Development Positive Regulation Of Axonogenesis Negative Regulation Of Cell Adhesion Plasma Membrane Raft Distribution Negative Regulation Of Immune System Process Helper T Cell Diapedesis Regulation Of Catalytic Activity Protein Phosphorylated Amino Acid Binding Regulation Of Leukocyte Mediated Cytotoxicity Response To Cholecystokinin Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Synapse Assembly Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Locomotion Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of GTPase Activity Regulation Of Cell Shape Cerebellar Neuron Development Regulation Of Axonogenesis Membrane Microdomain Regulation Of Cell Projection Organization Positive Regulation Of Cell Growth DN2 Thymocyte Differentiation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Immune Response Transmembrane Signaling Receptor Activity Negative Regulation Of B Cell Receptor Signaling Pathway Cell Adhesion Regulation Of Cell Motility Negative Regulation Of Immune Response Regulation Of Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Anatomical Structure Morphogenesis Diapedesis Positive Regulation Of Growth Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Endothelin Cellular Response To Endothelin Regulation Of Lymphocyte Mediated Immunity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?