PLXNB1

Gene Name		plexin B1
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Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Intracellular Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding
	Biological Process	Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Positive Regulation Of Rho GTPase Activity Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Pathways		Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-protein Interactions		10 interactors: ARHGEF11 ARHGEF12 KMT2A MET PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D
Entrez ID		5364
HPRD ID		03032
Ensembl ID		ENSG00000164050
Uniprot IDs		O43157
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Semaphorin-plexin Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Cell Development Response To External Stimulus Small GTPase Mediated Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Regulation Of Rho Protein Signal Transduction Anatomical Structure Morphogenesis Developmental Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Migration Actin Cytoskeleton Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Neurotrophin Signaling Pathway Actin Filament-based Process Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Locomotion Regulation Of Cellular Component Movement Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity Epithelial Cell Morphogenesis
Tagcloud ?		4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby