CTBP2 and SOX6

Number of citations of the paper that reports this interaction (PubMedID 11504872)
50

Data Source:
HPRD (in vivo)

		CTBP2	SOX6
Description		C-terminal binding protein 2	SRY-box transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Repressor Complex Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding NAD Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation	Cartilage Condensation Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Muscle Organ Development Spinal Cord Oligodendrocyte Cell Differentiation Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of DNA-templated Transcription Cartilage Development Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525) Walking pace ( 33128006)	Adolescent idiopathic scoliosis ( 30395268) Alanine aminotransferase levels ( 34315874 33547301) Anti-saccade response ( 25387707) Aspartate aminotransferase levels ( 34315874 33547301) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 23972371) Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (wrist) ( 21104366) Caffeine consumption from tea ( 33287642) Capecitabine sensitivity ( 22864933) Chronotype ( 30696823) Coronary artery disease ( 33020668 29212778) Cotinine glucuronidation ( 25293881) Depression ( 33859377) Diastolic blood pressure ( 25249183 30578418 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Experiencing mood swings ( 29500382) Femoral neck bone mineral density ( 22504420 32239398 26367794 29499414) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) General factor of neuroticism ( 30867560) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 25249183) Left-handedness ( 32989287) Liver enzyme levels (alanine transaminase) ( 33972514) Longevity (90 years and older) ( 25199915) Lumbar spine bone mineral density ( 26367794) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 32888494 27863252 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multisite chronic pain ( 33830993 31194737) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity and osteoporosis ( 19714249) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301) Smoking cessation ( 33082346) Systolic blood pressure ( 30578418 27841878 25249183) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 31046077)
Interacting Genes		96 interacting genes: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 BIRC2 BIRC3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DCAF6 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4	15 interacting genes: CENPK CTBP2 DAZAP2 ERG HDAC1 HNF1B NFIC NFIX POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 ZNF184
Entrez ID		1488	55553
HPRD ID		04016	06267
Ensembl ID		ENSG00000175029	ENSG00000110693
Uniprot IDs		P56545	P35712
PDB IDs		2OME 4LCJ 6WKW 8ATI
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Voltage-gated Calcium Channel Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Voltage-gated Calcium Channel Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process L-type Voltage-gated Calcium Channel Complex Positive Regulation Of Metabolic Process Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator High Voltage-gated Calcium Channel Activity Programmed Cell Death Protein K63-linked Ubiquitination Cell Death Regulation Of Signal Transduction By P53 Class Mediator Monoatomic Ion Channel Complex Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Protein Tag Activity Ubiquitin-like Protein Ligase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Binding PML Body DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Protein Modification Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Gene Expression Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Endoderm Development Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Corepressor Binding Regulation Of DNA Binding Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development DNA Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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