CTBP2 and RPS4X

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CTBP2	RPS4X
Description		C-terminal binding protein 2	ribosomal protein S4 X-linked
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GO Annotations	Cellular Component	Nucleus Transcription Repressor Complex Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding NAD Binding DNA-binding Transcription Factor Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation	Cytoplasmic Translation Translation Positive Regulation Of Cell Population Proliferation Ribosomal Small Subunit Biogenesis Positive Regulation Of Translation
Pathways		Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525) Walking pace ( 33128006)	Autism spectrum disorder ( 34069769)
Interacting Genes		96 interacting genes: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 BIRC2 BIRC3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DCAF6 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4	15 interacting genes: ARPC3 CAMK2D CTBP2 DUX4 HNRNPH3 MCM2 OGT PDE4B PTEN RPS15 RPS7 SUMO2 TRIM55 TRIM63 USP7
Entrez ID		1488	6191
HPRD ID		04016	02427
Ensembl ID		ENSG00000175029	ENSG00000198034
Uniprot IDs		P56545	B2R491 P62701
PDB IDs		2OME 4LCJ 6WKW 8ATI	4UG0 4V6X 5A2Q 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLI 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Voltage-gated Calcium Channel Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Voltage-gated Calcium Channel Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process L-type Voltage-gated Calcium Channel Complex Positive Regulation Of Metabolic Process Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator High Voltage-gated Calcium Channel Activity Programmed Cell Death Protein K63-linked Ubiquitination Cell Death Regulation Of Signal Transduction By P53 Class Mediator Monoatomic Ion Channel Complex Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Signaling Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Primary Metabolic Process Titin Binding Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Ubiquitin Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Relaxation Of Muscle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Signal Transduction PML Body Nucleus Regulation Of Signal Transduction By P53 Class Mediator Cytoplasmic Translation Myeloid Leukocyte Migration Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Positive Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of Rac Protein Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Protein Modification Process Response To Electrical Stimulus Cytosolic Small Ribosomal Subunit Protein Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Growth Cone Leading Edge Positive Regulation Of Proteolysis Regulation Of Macromolecule Metabolic Process Regulation Of Gluconeogenesis Regulation Of Glycolytic Process
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