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CTBP2 and ACTG1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
CTBP2
ACTG1
Description
C-terminal binding protein 2
actin gamma 1
Image
GO Annotations
Cellular Component
Nucleus
Transcription Repressor Complex
Synapse
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Myofibril
Axon
Filamentous Actin
NuA4 Histone Acetyltransferase Complex
Apical Junction Complex
Calyx Of Held
Apical Part Of Cell
Synapse
Phagocytic Vesicle
Extracellular Exosome
Blood Microparticle
Dense Body
Schaffer Collateral - CA1 Synapse
Basal Body Patch
Molecular Function
Transcription Coregulator Binding
Transcription Corepressor Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Protein Kinase Binding
Identical Protein Binding
Protein-containing Complex Binding
NAD Binding
DNA-binding Transcription Factor Binding
Nucleotide Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Profilin Binding
ATP Binding
Hydrolase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Viral Genome Replication
Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
White Fat Cell Differentiation
Angiogenesis
Morphogenesis Of A Polarized Epithelium
Axonogenesis
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Maintenance Of Blood-brain Barrier
Sarcomere Organization
Cell Motility
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Platelet Aggregation
Cellular Response To Type II Interferon
Positive Regulation Of Wound Healing
Postsynaptic Actin Cytoskeleton Organization
Tight Junction Assembly
Regulation Of Transepithelial Transport
Regulation Of Synaptic Vesicle Endocytosis
Protein Localization To Bicellular Tight Junction
Pathways
Repression of WNT target genes
Signaling by TCF7L2 mutants
Negative Regulation of CDH1 Gene Transcription
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
RHOBTB2 GTPase cycle
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Regulation of CDH1 Function
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Copper
Artenimol
Diseases
GWAS
Adult body size (
32376654
)
Age-related cognitive decline (visuospatial skill) (slope of z-scores) (
30954325
)
Age-related hearing impairment (
34108613
)
Apolipoprotein A1 levels (
32203549
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
Haemorrhoidal disease (
33888516
)
HDL cholesterol levels (
32203549
)
Height (
25429064
)
Hemoglobin levels (
32327693
)
Hip circumference adjusted for BMI (
34021172
)
Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) (
30188897
)
Menarche (age at onset) (
25231870
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Prostate cancer (
18264096
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Vigorous physical activity (
29899525
)
Walking pace (
33128006
)
Alanine aminotransferase levels (
33339817
33547301
)
Gamma glutamyl transferase levels (
33339817
)
Hand grip strength (
29313844
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Refractive error (
32231278
)
Interacting Genes
96 interacting genes:
ACTG1
AKTIP
APP
BAZ2B
BCAS3
BCL3
BIRC2
BIRC3
C15orf39
CACNB1
CACNB2
CACNB3
CACNB4
CAPN7
CASP8AP2
CATSPER1
CBX4
CCDC120
CCNH
CCR5
CDKN2A
CEP68
CSTF2
CTBP1
CTPS2
DCAF6
DMRTB1
DTNB
DUSP21
DVL2
EEF1D
EGLN3
EIF4G1
ELAC2
ENKD1
EP300
FHL3
FLI1
FUNDC1
GLIS2
H3-4
HEMGN
HIC1
HOXA5
HOXB5
HOXC5
IKZF2
KCNIP3
KLF3
KLF8
KYNU
LCORL
LMO4
MDM2
MECOM
NEK6
NOL4
NOL4L
NRIP1
PLCB1
PNN
PPP1R15A
PROX1
PSMF1
QARS1
RAI2
RBBP8NL
RIMBP3
RNF135
RPL17
RPL7A
RPS28
RPS29
RPS4X
SDCBP
SHISA6
SOX6
STUB1
STX11
TEAD3
TGIF1
TLE5
TRIML2
TSHZ3
UBC
UBE2I
VRTN
XRCC6
ZBP1
ZEB1
ZEB2
ZFPM1
ZFPM2
ZNF512B
ZNF750
ZSCAN4
72 interacting genes:
ABLIM1
ACTB
ANXA5
ATF7IP
BCAP31
BIN1
BRCA1
CAP1
CAP2
CAPZA3
CCDC22
CDC37
CDKN2A
CEBPA
CFL1
CFL2
COTL1
CTBP2
CTTN
CYBB
DISC1
DNASE1
DSTN
DUX4
DYNLL1
EHHADH
EIF6
FHOD1
FNDC3B
FPR1
GIT2
GSN
GZMA
GZMK
HRAS
HSPB2
LGALS13
LIG4
LINC00941
LINC01554
LSP1
MAP1A
MAPK6
MAPT
MCPH1
MYO1A
MYOC
NDRG1
NR3C2
NTAQ1
PFN2
PLD1
PLEC
PPP1R9A
PRSS23
PSEN2
PTPRO
RPS6KA5
SCIN
SH3GL2
SRPK2
ST3GAL3
SUMO4
TMSB4X
TMSB4Y
TNIK
VASP
VIL1
WASF1
WASL
WEE2-AS1
WIPF1
Entrez ID
1488
71
HPRD ID
04016
00017
Ensembl ID
ENSG00000175029
ENSG00000184009
Uniprot IDs
P56545
P63261
PDB IDs
2OME
4LCJ
6WKW
8ATI
5JLH
6CXI
6CXJ
6G2T
6V62
6V63
6WK1
6WK2
7NVM
8DNF
Enriched GO Terms of Interacting Partners
?
Nucleus
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Protein Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Voltage-gated Calcium Channel Activity
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Corepressor Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
SUMO Transferase Activity
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Voltage-gated Calcium Channel Complex
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
L-type Voltage-gated Calcium Channel Complex
Positive Regulation Of Metabolic Process
Apoptotic Process
Positive Regulation Of Signal Transduction By P53 Class Mediator
High Voltage-gated Calcium Channel Activity
Programmed Cell Death
Protein K63-linked Ubiquitination
Cell Death
Regulation Of Signal Transduction By P53 Class Mediator
Monoatomic Ion Channel Complex
Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Actin Binding
Actin Filament Organization
Actin Filament-based Process
Regulation Of Actin Filament Organization
Supramolecular Fiber Organization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Regulation Of Supramolecular Fiber Organization
Regulation Of Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament-based Process
Actin Cytoskeleton
Positive Regulation Of Cytoskeleton Organization
Actin Polymerization Or Depolymerization
Actin Filament Binding
Cytoskeleton
Actin Cytoskeleton Organization
Regulation Of Cellular Component Size
Regulation Of Actin Filament Polymerization
Regulation Of Organelle Organization
Actin Filament Severing
Cytoskeleton Organization
Regulation Of Cellular Component Organization
Positive Regulation Of Organelle Organization
Actin Filament Depolymerization
Modification Of Postsynaptic Actin Cytoskeleton
Regulation Of Actin Filament Depolymerization
Cortical Actin Cytoskeleton
Regulation Of Protein Depolymerization
Lamellipodium
Cell Projection Organization
Cytoplasm
Modification Of Postsynaptic Structure
Positive Regulation Of Cellular Component Organization
Modification Of Synaptic Structure
Regulation Of Protein-containing Complex Disassembly
Glutamatergic Synapse
Positive Regulation Of Actin Filament Depolymerization
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Cytoskeleton Organization
Actin Filament Fragmentation
Protein Depolymerization
Organelle Organization
Plasma Membrane Bounded Cell Projection Organization
Presynapse
Negative Regulation Of Actin Filament Depolymerization
Positive Regulation Of Protein Depolymerization
Barbed-end Actin Filament Capping
Positive Regulation Of Cellular Component Biogenesis
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