CTBP2 and CACNB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CTBP2	CACNB2
Description		C-terminal binding protein 2	calcium voltage-gated channel auxiliary subunit beta 2
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GO Annotations	Cellular Component	Nucleus Transcription Repressor Complex Synapse	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Sarcolemma Photoreceptor Ribbon Synapse Presynapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding NAD Binding DNA-binding Transcription Factor Binding	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Actin Filament Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Neuromuscular Junction Development Visual Perception Monoatomic Ion Transmembrane Transport Positive Regulation Of Muscle Contraction Positive Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Depolarization During AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase Sensory processing of sound by inner hair cells of the cochlea Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Nicardipine Nicardipine Magnesium sulfate Verapamil Levomenthol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Nilvadipine Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Brugada syndrome (BRS)
GWAS		Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525) Walking pace ( 33128006)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 34002096) Blood pressure ( 21909110) Body mass index ( 28892062) Brain volume in infants (grey matter) ( 28763065) Cadmium levels ( 26025379) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 21909115 28739976 27841878 27618452 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertension ( 31879980 19430479 21909115) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (HVA/MHPG ratio) ( 23319000) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Quantitative traits ( 19197348) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Schizophrenia ( 30285260 23974872 29483656 25056061 28991256) Small vessel stroke ( 26732560) Systolic blood pressure ( 21909115 27618452 27841878 19430479 28135244 28739976 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White matter hyperintensity volume ( 33293549)
Interacting Genes		96 interacting genes: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 BIRC2 BIRC3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DCAF6 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4	6 interacting genes: CTBP2 HEXIM2 PRKACA PRMT5 REM1 TMEM174
Entrez ID		1488	783
HPRD ID		04016	02473
Ensembl ID		ENSG00000175029	ENSG00000165995
Uniprot IDs		P56545	A0A494C0B2 A0A494C184 Q08289 Q59H42 Q5VVH1
PDB IDs		2OME 4LCJ 6WKW 8ATI	8HLP 8HMA 8HMB
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Voltage-gated Calcium Channel Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Voltage-gated Calcium Channel Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process L-type Voltage-gated Calcium Channel Complex Positive Regulation Of Metabolic Process Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator High Voltage-gated Calcium Channel Activity Programmed Cell Death Protein K63-linked Ubiquitination Cell Death Regulation Of Signal Transduction By P53 Class Mediator Monoatomic Ion Channel Complex Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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