CTBP2 and STX11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CTBP2	STX11
Description		C-terminal binding protein 2	syntaxin 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Repressor Complex Synapse	Golgi Apparatus Plasma Membrane Endomembrane System Membrane SNARE Complex Presynaptic Active Zone Membrane
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding NAD Binding DNA-binding Transcription Factor Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation	Intracellular Protein Transport Exocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion
Pathways		Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases			Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525) Walking pace ( 33128006)	Nicotine dependence symptom count ( 25555482) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		96 interacting genes: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 BIRC2 BIRC3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DCAF6 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4	98 interacting genes: AIRIM APP AXIN1 AXIN2 BLOC1S6 BYSL CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A MTCL2 NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNCA SNX3 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587
Entrez ID		1488	8676
HPRD ID		04016	09231
Ensembl ID		ENSG00000175029	ENSG00000135604
Uniprot IDs		P56545	O75558
PDB IDs		2OME 4LCJ 6WKW 8ATI
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Voltage-gated Calcium Channel Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Voltage-gated Calcium Channel Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process L-type Voltage-gated Calcium Channel Complex Positive Regulation Of Metabolic Process Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator High Voltage-gated Calcium Channel Activity Programmed Cell Death Protein K63-linked Ubiquitination Cell Death Regulation Of Signal Transduction By P53 Class Mediator Monoatomic Ion Channel Complex Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Identical Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex SNARE Complex Assembly Protein Binding SNAP Receptor Activity SNARE Complex Synaptic Vesicle Docking Synaptic Vesicle Exocytosis SNARE Binding Regulation Of Cellular Response To Stress Regulation Of DNA Repair BLOC-1 Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Priming Establishment Of Localization In Cell Membrane Docking Establishment Of Organelle Localization Positive Regulation Of Proteolysis Positive Regulation Of Synaptic Transmission Syntaxin Binding Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of RNA Metabolic Process Transcription Coactivator Activity Neurotransmitter Transport Vesicle Fusion Membrane Fusion Long-term Synaptic Potentiation Regulation Of Gene Expression Organelle Membrane Fusion Organelle Localization Establishment Of Vesicle Localization Host-mediated Perturbation Of Symbiont Process DNA Repair-dependent Chromatin Remodeling Regulation Of DNA-templated Transcription Nuclear Androgen Receptor Binding Vesicle Organization Vesicle Docking Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Modulation Of Process Of Another Organism Microtubule-based Process Vesicle Localization Neuron Projection Nucleoplasm
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