CTBP2 and RNF135

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CTBP2	RNF135
Description		C-terminal binding protein 2	ring finger protein 135
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GO Annotations	Cellular Component	Nucleus Transcription Repressor Complex Synapse	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding NAD Binding DNA-binding Transcription Factor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity RIG-I Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation	Protein Polyubiquitination Immune System Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Positive Regulation Of Interferon-beta Production RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Protein Homooligomerization Protein K63-linked Ubiquitination Antiviral Innate Immune Response
Pathways		Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525) Walking pace ( 33128006)	Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		96 interacting genes: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 BIRC2 BIRC3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DCAF6 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4	10 interacting genes: CTBP2 ENOX2 GOLGA2 HSF2BP IFIH1 MAVS RIGI TEPSIN UBE2D2 UBE2N
Entrez ID		1488	84282
HPRD ID		04016	11506
Ensembl ID		ENSG00000175029	ENSG00000181481
Uniprot IDs		P56545	B3KV69 Q8IUD6
PDB IDs		2OME 4LCJ 6WKW 8ATI	7JL1 7JL3 8G7T 8G7U 8G7V
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Voltage-gated Calcium Channel Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Voltage-gated Calcium Channel Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process L-type Voltage-gated Calcium Channel Complex Positive Regulation Of Metabolic Process Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator High Voltage-gated Calcium Channel Activity Programmed Cell Death Protein K63-linked Ubiquitination Cell Death Regulation Of Signal Transduction By P53 Class Mediator Monoatomic Ion Channel Complex Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Antiviral Innate Immune Response Cellular Response To Exogenous DsRNA Cellular Response To DsRNA Positive Regulation Of Interferon-alpha Production Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Detection Of Virus Response To DsRNA MRNA Transcription Regulation Of Type III Interferon Production Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Positive Regulation Of Response To Cytokine Stimulus Defense Response To Virus Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Response To Virus Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Activation Of Immune Response DNA-templated Transcription Regulation Of Interleukin-6 Production Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Activation Of Innate Immune Response Pattern Recognition Receptor Activity Intracellular Receptor Signaling Pathway Regulation Of Defense Response To Virus By Host Single-stranded RNA Binding Innate Immune Response Negative Regulation Of Viral Genome Replication Positive Regulation Of Immune Response Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Production Positive Regulation Of IP-10 Production Coated Vesicle Membrane Defense Response To Symbiont Positive Regulation Of Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Other Organism
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