AGFG1 and EPS15L1

Number of citations of the paper that reports this interaction (PMID 10613896)
16

Data Source:
HPRD (in vivo, two hybrid)

		AGFG1	EPS15L1
Gene Name		ArfGAP with FG repeats 1	epidermal growth factor receptor pathway substrate 15-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Cytoplasmic Membrane-bounded Vesicle Cell Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Nucleus Plasma Membrane Coated Pit Membrane
	Molecular Function	DNA Binding RNA Binding Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	Acrosome Assembly MRNA Export From Nucleus Multicellular Organismal Development Spermatid Nucleus Differentiation Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Intermediate Filament Organization	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Multiple sclerosis ( 22190364) White blood cell count ( 21738480) White matter integrity ( 23218918)
Protein-Protein Interactions		11 interactors: APC APP EPS15 EPS15L1 ITSN1 NYAP2 PKIA POLE2 RNF216 VAMP7 XPO1	8 interactors: AGFG1 AGFG2 EPN1 GNG5 ITSN1 ITSN2 STON2 TRAPPC2B
Entrez ID		3267	58513
HPRD ID		02918	09445
Ensembl ID		ENSG00000173744	ENSG00000127527
Uniprot IDs		P52594	Q9UBC2
PDB IDs		2D9L 2OLM 2VX8
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Cycle Phase Transition Neuron Projection Morphogenesis Regulation Of Intracellular Protein Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Regulation Of Protein Localization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Protein Targeting To Vacuolar Membrane Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Signal Transduction Neuron Development Apoptotic Process Post-Golgi Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Localization Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cell Death Death Cell Morphogenesis Negative Regulation Of Signal Transduction Establishment Of Localization In Cell Neuron Differentiation Cell Surface Receptor Signaling Pathway Cell Projection Organization Ribosomal Small Subunit Export From Nucleus Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Collateral Sprouting In Absence Of Injury Triglyceride Transport Negative Regulation Of Signaling Axonogenesis Regulation Of Microtubule Cytoskeleton Organization Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity	Regulation Of Ras GTPase Activity Endocytosis Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Positive Regulation Of Hydrolase Activity Regulation Of ARF GTPase Activity Regulation Of Signal Transduction Regulation Of ARF Protein Signal Transduction Vesicle-mediated Transport Synaptic Vesicle Transport Synaptic Transmission Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Intracellular Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Establishment Of Organelle Localization Regulation Of Rho Protein Signal Transduction Acrosome Assembly Intermediate Filament Organization Transport Organelle Localization Positive Regulation Of Ras GTPase Activity Regulation Of Cellular Process Spermatid Nucleus Differentiation Positive Regulation Of Metabolic Process
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