AGFG1 and RNF216

Number of citations of the paper that reports this interaction (PubMedID 11854271)
0

Data Source:
HPRD (in vivo)

		AGFG1	RNF216
Description		ArfGAP with FG repeats 1	ring finger protein 216
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Cytoplasm Cytosol Cytoplasmic Vesicle Cell Projection Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle
	Molecular Function	DNA Binding RNA Binding GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Acrosome Assembly MRNA Export From Nucleus Spermatogenesis Spermatid Nucleus Differentiation Cell Differentiation Intermediate Filament Organization MRNA Transport	Apoptotic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Airway hyperresponsiveness ( 23984888) Asthma ( 31959851) Mild influenza (H1N1) infection ( 26379185)	Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)
Interacting Genes		15 interacting genes: APC APP DNAJC5 EPS15 EPS15L1 ITSN1 MFHAS1 NYAP2 OGT PKIA POLE2 RNF216 TRIM54 VAMP7 XPO1	33 interacting genes: AGFG1 BRCA1 CAPN15 DYRK1A FAM168A FLNB KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 STAU2 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		3267	54476
HPRD ID		02918	15550
Ensembl ID		ENSG00000173744	ENSG00000011275
Uniprot IDs		A0A0S2Z444 P52594	A8K8N1 Q9NWF9
PDB IDs		2D9L 2OLM 2VX8	7M4M 7M4N 7M4O 8EB0
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Vesicle-mediated Transport In Synapse Regulation Of Protein Localization Negative Regulation Of Protein Localization To Nucleus Clathrin Coat Of Coated Pit Establishment Of Localization In Cell Postsynaptic Endocytic Zone Vesicle-mediated Transport Intracellular Transport Platelet Alpha Granule Cytoplasm Plasma Membrane Bounded Cell Projection Cellular Localization Regulation Of Protein Catabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Protein Localization To Nucleus Regulation Of Microtubule Depolymerization Negative Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Negative Regulation Of Microtubule Polymerization Or Depolymerization Lamellipodium Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Endocytosis Cytoplasmic Vesicle Negative Regulation Of CAMP-dependent Protein Kinase Activity Presynaptic Endocytosis Synaptic Vesicle Endocytosis Exocytosis Negative Regulation Of Type I Interferon Production Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Signal Transduction Regulation Of Mitotic Cell Cycle Protein-containing Complex Organization Apoptotic Process Presynapse Regulation Of Glycolytic Process Programmed Cell Death Negative Regulation Of Protein Localization Synapse Protein-macromolecule Adaptor Activity Azurophil Granule Membrane Cell Death	Ubiquitin Conjugating Enzyme Activity Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Positive Regulation Of Defense Response Proteolysis Proteolysis Involved In Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Macromolecule Catabolic Process Regulation Of Interleukin-8 Production Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Immune Response-regulating Signaling Pathway Endosome Membrane Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Type I Interferon Production Regulation Of Immune Response Protein Autoubiquitination Positive Regulation Of Metabolic Process Activation Of Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein K6-linked Ubiquitination Response To Stress Positive Regulation Of Interferon-alpha Production Protein K48-linked Deubiquitination Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process
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