AGFG1 and XPO1

Number of citations of the paper that reports this interaction (PubMedID 9368759)
0

Data Source:
HPRD (two hybrid, in vitro)

		AGFG1	XPO1
Description		ArfGAP with FG repeats 1	exportin 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Pore Cytoplasm Cytosol Cytoplasmic Vesicle Cell Projection Neuronal Cell Body	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding DNA-binding Transcription Factor Binding
	Biological Process	Acrosome Assembly MRNA Export From Nucleus Spermatogenesis Spermatid Nucleus Differentiation Cell Differentiation Intermediate Filament Organization MRNA Transport	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport Cellular Response To Triglyceride Cellular Response To Salt
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Selinexor
Diseases
GWAS		Airway hyperresponsiveness ( 23984888) Asthma ( 31959851) Mild influenza (H1N1) infection ( 26379185)	Atrial fibrillation ( 29892015) Eosinophil count ( 27863252 32888494) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: APC APP DNAJC5 EPS15 EPS15L1 ITSN1 MFHAS1 NYAP2 OGT PKIA POLE2 RNF216 TRIM54 VAMP7 XPO1	86 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDK1 CDKN1B CEBPA CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF4E EIF5A ERF FBXO7 FILNC1 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 LRPPRC MAPK6 NF2 NMD3 NOSIP NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB1 PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		3267	7514
HPRD ID		02918	03975
Ensembl ID		ENSG00000173744	ENSG00000082898
Uniprot IDs		A0A0S2Z444 P52594	A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980
PDB IDs		2D9L 2OLM 2VX8	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO 7B51 9B62
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Vesicle-mediated Transport In Synapse Regulation Of Protein Localization Negative Regulation Of Protein Localization To Nucleus Clathrin Coat Of Coated Pit Establishment Of Localization In Cell Postsynaptic Endocytic Zone Vesicle-mediated Transport Intracellular Transport Platelet Alpha Granule Cytoplasm Plasma Membrane Bounded Cell Projection Cellular Localization Regulation Of Protein Catabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Protein Localization To Nucleus Regulation Of Microtubule Depolymerization Negative Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Negative Regulation Of Microtubule Polymerization Or Depolymerization Lamellipodium Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Endocytosis Cytoplasmic Vesicle Negative Regulation Of CAMP-dependent Protein Kinase Activity Presynaptic Endocytosis Synaptic Vesicle Endocytosis Exocytosis Negative Regulation Of Type I Interferon Production Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Signal Transduction Regulation Of Mitotic Cell Cycle Protein-containing Complex Organization Apoptotic Process Presynapse Regulation Of Glycolytic Process Programmed Cell Death Negative Regulation Of Protein Localization Synapse Protein-macromolecule Adaptor Activity Azurophil Granule Membrane Cell Death	Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Nucleoplasm Nucleus Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cytoplasm Intracellular Transport Protein Export From Nucleus Regulation Of Primary Metabolic Process RNA Transport Establishment Of Localization In Cell Protein Import Into Nucleus Import Into Nucleus Cellular Localization Intracellular Protein Transport Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Nuclear Pore Establishment Of Protein Localization To Organelle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Transport Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Protein Localization To Nucleus Cytosol Positive Regulation Of Metabolic Process RNA Export From Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Negative Regulation Of Mitotic Cell Cycle DNA Binding MRNA Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription
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