STAM2 and ENTREP1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		STAM2	ENTREP1
Description		signal transducing adaptor molecule 2	endosomal transmembrane epsin interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Cytosol Membrane Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex	Endosome Plasma Membrane Membrane Early Endosome Membrane Late Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding	Protein Binding Ubiquitin Ligase Activator Activity
	Biological Process	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Negative Adaptation Of Signaling Pathway Receptor Internalization CXCL12-activated CXCR4 Signaling Pathway
Pathways		EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		37 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR ENTREP1 EPS15 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN4 USP8 VPS37C XRN1 ZC3H10	11 interacting genes: BAG3 CALCOCO2 NEDD4 OPTN SFN STAM2 TAX1BP1 UBQLN1 UBXN1 WWP1 WWP2
Entrez ID		10254	9413
HPRD ID		05876	16255
Ensembl ID		ENSG00000115145	ENSG00000135063
Uniprot IDs		O75886	Q15884 Q8WU02
PDB IDs		1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?		Endosome Growth Hormone Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Early Endosome Proteolysis Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Plasma Membrane Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Protein Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein K48-linked Ubiquitination Protein-containing Complex Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Signal Transduction Early Endosome Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Type II Interferon-mediated Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Cell Communication Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Interleukin-12 Receptor Complex Ubiquitin-protein Transferase Activity Protein Autoubiquitination Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Interleukin-23 Receptor Complex Cytosol Protein Polyubiquitination Endosome Membrane Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Proteasomal Protein Catabolic Process Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation CXCL12-activated CXCR4 Signaling Pathway	Catabolic Process Autophagy Regulation Of Macroautophagy Autophagosome Polyubiquitin Modification-dependent Protein Binding Regulation Of Autophagy Macroautophagy Cytosol Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cation Transmembrane Transport Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Potassium Channel Inhibitor Activity Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Macroautophagy Negative Regulation Of Monoatomic Ion Transport Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin Ligase Complex Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Cytoplasm Cellular Response To Unfolded Protein Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Cellular Response To Topologically Incorrect Protein Negative Regulation Of Potassium Ion Transport Positive Regulation Of Autophagy Proteasomal Protein Catabolic Process Aggresome Regulation Of Protein Export From Nucleus Intracellular Protein Transport Protein-macromolecule Adaptor Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Transport Intracellular Protein Localization Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Organelle Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport
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