STAM2 and TIMM8A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		STAM2	TIMM8A
Gene Name		signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	translocase of inner mitochondrial membrane 8 homolog A (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Early Endosome Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space
	Molecular Function	Protein Binding	Metal Ion Binding
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Protein Targeting To Mitochondrion Nervous System Development Cellular Protein Metabolic Process Chaperone-mediated Protein Transport
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ABI2 ARRDC3 ATXN1 CBX5 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN4 USP8 VPS37C XRN1	4 interactors: KRT15 STAM STAM2 TIMM13
Entrez ID		10254	1678
HPRD ID		05876	02287
Ensembl ID		ENSG00000115145	ENSG00000126953
Uniprot IDs		O75886	O60220
PDB IDs		1X2Q 1X5B 2L0T
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Protein K48-linked Ubiquitination Protein Polyubiquitination Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Immune Response Regulation Of Immune System Process Defense Response Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Catabolic Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress JAK-STAT Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Activation Of Innate Immune Response Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Toll-like Receptor 4 Signaling Pathway Regulation Of Signal Transduction Regulation Of ERBB Signaling Pathway Positive Regulation Of Innate Immune Response Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Signal Transduction Protein Autophosphorylation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Hypoxia	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endosomal Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Extracellular Vesicular Exosome Assembly Intracellular Transport Chaperone-mediated Protein Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Localization Establishment Of Localization In Cell Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Exocytosis Protein Targeting To Mitochondrion Negative Regulation Of Signal Transduction Protein Localization To Mitochondrion Negative Regulation Of Signaling
Tagcloud ?		adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating	coil coiled coordinates ddp deafness downs dystonia endosomal endosomes hepatocyte immunoreceptor import imported intermembrane itam jensen localizes mohr optic overlaps pull redistribution ribosomes stam1 tranebjaerg transducing translated ultimately zn
Tagcloud (Difference) ?		adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 ut7epo validating	coil coiled coordinates ddp deafness downs dystonia endosomal endosomes hepatocyte immunoreceptor import imported intermembrane itam jensen localizes mohr optic overlaps pull redistribution ribosomes stam1 tranebjaerg translated ultimately zn
Tagcloud (Intersection) ?		transducing