STAM2 and L3MBTL2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		STAM2	L3MBTL2
Gene Name		signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	l(3)mbt-like 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Early Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ABI2 ARRDC3 ATXN1 CBX5 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN4 USP8 VPS37C XRN1	14 interactors: AES CBX3 HIST1H3A HIST1H4A MEAF6 MPP3 PAICS PHF10 PIAS1 RNF2 STAC3 STAM2 TBC1D9B TRIM42
Entrez ID		10254	83746
HPRD ID		05876	13954
Ensembl ID		ENSG00000115145	ENSG00000100395
Uniprot IDs		O75886	Q969R5
PDB IDs		1X2Q 1X5B 2L0T	2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Protein K48-linked Ubiquitination Protein Polyubiquitination Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Immune Response Regulation Of Immune System Process Defense Response Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Catabolic Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress JAK-STAT Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Activation Of Innate Immune Response Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Toll-like Receptor 4 Signaling Pathway Regulation Of Signal Transduction Regulation Of ERBB Signaling Pathway Positive Regulation Of Innate Immune Response Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Signal Transduction Protein Autophosphorylation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Hypoxia	DNA Replication-dependent Nucleosome Assembly Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Organization Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Protein-DNA Complex Assembly Gene Expression Chromosome Organization Chromatin Silencing Chromatin Modification Negative Regulation Of Cellular Metabolic Process DNA Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process RNA Biosynthetic Process DNA Modification Histone Modification Histone H2A-K119 Monoubiquitination Gene Silencing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Histone H4-K20 Demethylation Regulation Of Cellular Process Nucleosome Assembly Positive Regulation Of Anoikis Chromatin Assembly Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Nucleosome Organization Chromatin Assembly Or Disassembly 'de Novo' IMP Biosynthetic Process Histone H3-K14 Acetylation RNA Metabolic Process Cellular Macromolecular Complex Assembly Chromatin Remodeling DNA Packaging Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Tagcloud ?		adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating	700r analyse balancing compaction competent defective dub essentially facilitates flag h2aub1 hek293 integral k675 lethal occupancy occupied polycomb prc1 repressed repressive ring2 seq stably sumo2 sumoylation tagged tails ubiquitinating
Tagcloud (Difference) ?		adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating	700r analyse balancing compaction competent defective dub essentially facilitates flag h2aub1 hek293 integral k675 lethal occupancy occupied polycomb prc1 repressed repressive ring2 seq stably sumo2 sumoylation tagged tails ubiquitinating
Tagcloud (Intersection) ?