HAX1 and POLR1D

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HAX1	POLR1D
Gene Name		HCLS1 associated protein X-1	polymerase (RNA) I polypeptide D, 16kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Transcription Factor Complex Mitochondrion Endoplasmic Reticulum Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane	Nucleoplasm DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol
	Molecular Function	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Protein N-terminus Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding Protein Dimerization Activity
	Biological Process	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Mitochondrion Degradation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic
Pathways			RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Termination NoRC negatively regulates rRNA expression RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Chain Elongation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC RBX1 RPA1 STAT5B SVIL YWHAQ ZNF420 ZNRD1	15 interactors: CD3EAP CDC25A CRKL DDIT3 DNAJB4 DNAJB6 E2F4 GRB2 HAX1 MAGEA11 MRPL12 NFKBIB NR3C1 POLR1C PXN
Entrez ID		10456	51082
HPRD ID		12075	17877
Ensembl ID		ENSG00000143575	ENSG00000186184
Uniprot IDs		O00165	Q9Y2S0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Positive Regulation Of Interleukin-2 Production Xenobiotic Transport Response To Abiotic Stimulus Positive Regulation Of Transport DNA-templated Transcription, Initiation Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cellular Localization Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Cytokine Production Regulation Of Establishment Of Protein Localization Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Drug Transmembrane Transport Positive Regulation Of Cation Channel Activity Transcription From RNA Polymerase I Promoter Immune System Process Response To Stress Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transporter Activity Acute-phase Response Regulation Of Intracellular Transport Positive Regulation Of Innate Immune Response Actin Filament Polymerization Protein Monoubiquitination Positive Regulation Of Intracellular Signal Transduction Drug Transport Signal Transduction Negative Regulation Of Ion Transmembrane Transport Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ion Transmembrane Transporter Activity Metanephric Cortex Development Metanephric Cortical Collecting Duct Development JAK-STAT Cascade	Response To Organic Substance Cellular Response To Organic Substance Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Termination Of RNA Polymerase I Transcription Regulation Of Phosphorus Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transcription Elongation From RNA Polymerase I Promoter Response To Stimulus Transcription Initiation From RNA Polymerase I Promoter Cellular Metabolic Process Transcription, DNA-templated Transcription From RNA Polymerase I Promoter RNA Biosynthetic Process Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Determination Of Dorsal Identity Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Kinase Activity Cellular Response To Stimulus Regulation Of Cellular Component Size DNA-templated Transcription, Termination Positive Regulation Of Neuron Death Negative Regulation Of Gene Expression, Epigenetic Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production RNA Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription Involved In Anterior/posterior Axis Specification Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Biosynthetic Process Response To Stress Gene Expression Nucleobase-containing Compound Metabolic Process
Tagcloud ?		1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish	anomalies cleft collins craniofacial daughters exome exon2 father favored feil hypoplasia inc kfs klippel l111p mandibular nonsynonymous palate pathogenetic periodicals predated rarity segmentation suggestive t332c tcs treacher wiley zygomatic
Tagcloud (Difference) ?		1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish	anomalies cleft collins craniofacial daughters exon2 father favored feil hypoplasia inc kfs klippel l111p mandibular nonsynonymous palate pathogenetic periodicals predated rarity segmentation suggestive t332c tcs treacher wiley zygomatic
Tagcloud (Intersection) ?		exome