HAX1 and PPP3CC

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HAX1	PPP3CC
Description		HCLS1 associated protein X-1	protein phosphatase 3 catalytic subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nuclear Envelope Transcription Regulator Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Cytoplasmic Vesicle Nuclear Membrane	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Protein Serine/threonine Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Signaling Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding
	Biological Process	Mitochondrion Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion	Protein Dephosphorylation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways			Activation of BAD and translocation to mitochondria DARPP-32 events
Drugs
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)
Interacting Genes		26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL WEE2-AS1 YWHAQ ZNF420	13 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC PPP3R1 SDC2 TGFBR1 THAP7 UNC119
Entrez ID		10456	5533
HPRD ID		12075	00236
Ensembl ID		ENSG00000143575	ENSG00000120910
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	P48454
PDB IDs			7U0T
Enriched GO Terms of Interacting Partners?		Ceramide Floppase Activity Ceramide Translocation Cytosol Regulation Of Transport Sphingolipid Translocation Phosphatidylcholine Floppase Activity ABC-type Transporter Activity Intercellular Canaliculus Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Import Transmembrane Transporter Binding Dendritic Spine Maintenance ATPase-coupled Intramembrane Lipid Transporter Activity Regulation Of Interleukin-2 Production Homeostatic Process Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Regulation Of Calcium Ion Import Across Plasma Membrane RNA Polymerase I Complex Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Ceramide Transport Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Cytoplasm Negative Regulation Of Monoatomic Ion Transport Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Dendritic Spine Organization Response To Copper Ion Multicellular Organismal-level Homeostasis Positive Regulation Of Interleukin-2 Production Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Phospholipid Translocation ATPase-coupled Transmembrane Transporter Activity Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Transmembrane Transport Type 8 Metabotropic Glutamate Receptor Binding	Regulation Of Extrinsic Apoptotic Signaling Pathway Heparan Sulfate Binding Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Transmembrane Receptor Protein Serine/threonine Kinase Activity Cytoplasmic Vesicle Synapse Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Regulation Of Cellular Component Organization PTB Domain Binding Cell Projection Morphogenesis Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import System Development Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Positive Regulation Of Calcium-mediated Signaling Regulation Of Signal Transduction Regulation Of Multicellular Organism Growth Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Lipoprotein Particle Positive Regulation Of Cell Differentiation Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?