HAX1 and BIRC3

Number of citations of the paper that reports this interaction (PMID 25275296)
0

Data Source:
BioGRID (pull down, pull down)

		HAX1	BIRC3
Gene Name		HCLS1 associated protein X-1	baculoviral IAP repeat containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Transcription Factor Complex Mitochondrion Endoplasmic Reticulum Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Membrane Raft
	Molecular Function	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Protein N-terminus Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Mitochondrion Degradation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Spermatogenesis Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Regulation Of Inflammatory Response Protein Heterooligomerization Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System
Drugs
Diseases
GWAS			MRI atrophy measures ( 21116278) Prostate cancer ( 23535732)
Protein-Protein Interactions		23 interactors: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC RBX1 RPA1 STAT5B SVIL YWHAQ ZNF420 ZNRD1	37 interactors: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19
Entrez ID		10456	330
HPRD ID		12075	03426
Ensembl ID		ENSG00000143575	ENSG00000023445
Uniprot IDs		O00165	Q13489
PDB IDs			2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Positive Regulation Of Interleukin-2 Production Xenobiotic Transport Response To Abiotic Stimulus Positive Regulation Of Transport DNA-templated Transcription, Initiation Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cellular Localization Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Cytokine Production Regulation Of Establishment Of Protein Localization Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Drug Transmembrane Transport Positive Regulation Of Cation Channel Activity Transcription From RNA Polymerase I Promoter Immune System Process Response To Stress Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transporter Activity Acute-phase Response Regulation Of Intracellular Transport Positive Regulation Of Innate Immune Response Actin Filament Polymerization Protein Monoubiquitination Positive Regulation Of Intracellular Signal Transduction Drug Transport Signal Transduction Negative Regulation Of Ion Transmembrane Transport Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ion Transmembrane Transporter Activity Metanephric Cortex Development Metanephric Cortical Collecting Duct Development JAK-STAT Cascade	Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Activation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Apoptotic Process Programmed Cell Death Regulation Of Immune Response Cell Death Death Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Cysteine-type Endopeptidase Activity Defense Response Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Immune Response Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Positive Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Difference) ?		1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Intersection) ?