STAMBPL1 and ECSIT

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		STAMBPL1	ECSIT
Description		STAM binding protein like 1	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Protein Binding Molecular Adaptor Activity
	Biological Process	Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Protein K63-linked Deubiquitination Cellular Response To L-leucine Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Metalloprotease DUBs	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS			Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		38 interacting genes: A2M BIRC5 CALCOCO2 CDC37 CEP72 COPS5 COPS6 DUSP1 ECSIT ENOX2 GCSAML GNPTAB GOLGA2 GOLGA6L9 IKZF3 INCA1 LAX1 LCOR MAGEA6 MAST1 MORN5 PLEKHF2 PNMA1 PSEN1 RAB2A RAB2B REL RNF32 SESN2 SF3B5 SMAD2 SMAD7 TCF4 TRIM27 TRIP13 UBC ZNF835 ZRANB1	53 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		57559	51295
HPRD ID		16486	12225
Ensembl ID		ENSG00000138134	ENSG00000130159
Uniprot IDs		Q96FJ0	Q9BQ95
PDB IDs		2ZNR 2ZNV 7L97
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse
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