ANXA6 and S100A1

Number of citations of the paper that reports this interaction (PubMedID 9883272)
0

Data Source:
HPRD (in vitro)

		ANXA6	S100A1
Description		annexin A6	S100 calcium binding protein A1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Plasma Membrane Focal Adhesion Vesicle Membrane Membrane Extracellular Matrix Late Endosome Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Sarcoplasmic Reticulum Z Disc M Band A Band I Band Protein-containing Complex
	Molecular Function	Phosphatidylserine Binding Calcium Ion Binding Protein Binding GTP Binding Calcium-dependent Phospholipid Binding Lipid Binding Ligand-gated Monoatomic Ion Channel Activity Cholesterol Binding Identical Protein Binding Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Calcium Ion Transport Regulation Of Muscle Contraction Monoatomic Ion Transmembrane Transport Negative Regulation Of Sequestering Of Calcium Ion Mitochondrial Calcium Ion Homeostasis Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Vasodilation Positive Regulation Of Sprouting Angiogenesis
Pathways		Smooth Muscle Contraction	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs			Olopatadine
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Lymphocyte count ( 32888494) Psoriasis ( 25574825 25903422) Psoriatic arthritis ( 26626624)
Interacting Genes		19 interacting genes: A2M CDC73 CEBPA CR2 ERBB2 IL16 LINC00632 LINC01554 MLH1 MTNR1B OGT PDE4B RASA1 RHOU S100A1 S100B SMURF1 SNCA TPD52	36 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 CLCF1 CNTF CTF1 DES FKBP4 GFAP GJA1 IFNB1 IL11 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1 TP53
Entrez ID		309	6271
HPRD ID		00231	01489
Ensembl ID		ENSG00000197043	ENSG00000160678
Uniprot IDs		A0A0S2Z2Z6 A0A0S2Z377 P08133	A0A0S2Z4H2 P23297
PDB IDs		1M9I	2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89
Enriched GO Terms of Interacting Partners?		Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Signaling Receptor Binding Calcium-dependent Protein Binding Cellular Developmental Process Negative Regulation Of Complement Activation Signal Transduction Regulation Of Developmental Process Cellular Response To Epinephrine Stimulus S100 Protein Binding Response To Epinephrine Regulation Of Cell Morphogenesis Regulation Of Anatomical Structure Morphogenesis Regulation Of Complement Activation Leukocyte Activation Regulation Of Cell Shape Developmental Process Regulation Of Cell Activation Regulation Of Signal Transduction Cell Activation Enzyme Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Cell Surface Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Homodimerization Activity Positive Regulation Of Inflammatory Response Regulation Of Programmed Cell Death Regulation Of Biological Quality Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Neuron Apoptotic Process Tau Protein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Engulfment Of Target By Autophagosome Growth Factor Binding B Cell Activation Regulation Of Humoral Immune Response Positive Regulation Of Proteolysis Carbohydrate Homeostasis Glucose Homeostasis Response To Lipid Lymphocyte Activation Negative Regulation Of Complement Activation, Lectin Pathway	Calcium-dependent Protein Binding S100 Protein Binding Transition Metal Ion Binding Identical Protein Binding Calcium Ion Binding Calcium Ion-transporting ATPase Complex Negative Regulation Of Blood Circulation Regulation Of Blood Circulation Regulation Of System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Actinomycin D Cell Surface Receptor Signaling Pathway Via STAT Cell Body Response To Actinomycin D Cellular Response To UV-C Ciliary Neurotrophic Factor Receptor Binding Sarcoplasmic Reticulum Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cardiac Muscle Cell Membrane Potential Cytokine Activity Intercalated Disc Muscle System Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Antibiotic Negative Regulation Of ATP-dependent Activity RAGE Receptor Binding Developmental Process Relaxation Of Cardiac Muscle Response To Hypoxia Cell Activation Response To UV-C Sarcoplasmic Reticulum Response To Decreased Oxygen Levels Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Modulation Of Chemical Synaptic Transmission Regulation Of Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Response To Oxygen Levels Astrocyte Activation Astrocyte Development Intracellular Calcium Ion Homeostasis Regulation Of Programmed Cell Death Regulation Of Heart Contraction Relaxation Of Muscle Cellular Response To UV Negative Regulation Of Heart Contraction Circadian Behavior Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Rhythmic Behavior
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