KRTAP5-2 and AP4M1

Number of citations: 82 (PubMedID 36949045)
Data Source: BioGRID (two hybrid)

		KRTAP5-2	AP4M1
Name		keratin associated protein 5-2	adaptor related protein complex 4 subunit mu 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Cytoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Protein Domain Specific Binding
	Biological Process	None	Autophagosome Assembly Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Transmembrane Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane
Pathways		Keratinization	Lysosome Vesicle Biogenesis
Drugs		Beta-D-Glucose Pidolic acid	None
Diseases		None	Cerebral palsy
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Refractive error ( 32231278 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		61 interacting genes: ADAMTSL4 AP4M1 CRCT1 CREB5 CRY2 DHRS1 DLGAP3 EMC7 FAM76B FUCA2 HOXA1 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LMNTD2 MACO1 MEOX2 MT1B NUFIP2 OPCML SLC13A5 SMCP TACSTD2 UBE2I	16 interacting genes: ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B HOOK1 HOOK2 KRTAP5-2 LAMP2 TGOLN2 USP47 ZBTB22
Entrez ID		440021	9179
HPRD ID		17249	03803
Ensembl ID		ENSG00000205867	ENSG00000221838
Uniprot IDs		Q701N4	C9JC87 C9JWL4 H7C0A0 O00189
PDB IDs		Not available	3L81 4MDR
GO Terms Enriched among Interactors		Intermediate Filament Keratinization Epidermis Development Keratin Filament Tissue Development Hair Cycle Protein Binding Identical Protein Binding	Postsynaptic Density Membrane Ligand-gated Monoatomic Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential FHF Complex Synaptic Transmission, Glutamatergic Intracellular Protein Localization Platelet Dense Granule Membrane Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Protein Localization To Perinuclear Region Of Cytoplasm Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Excitatory Chemical Synaptic Transmission Cellular Localization Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Ion Transmembrane Transport Calcium Ion Transport HOPS Complex Modulation Of Chemical Synaptic Transmission Somatodendritic Compartment Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Transport Lysosomal Transport Inorganic Cation Transmembrane Transport Early Endosome To Late Endosome Transport Monoatomic Cation Transmembrane Transport AMPA Glutamate Receptor Complex Dynein Light Intermediate Chain Binding Positive Regulation Of Synaptic Transmission Late Endosome Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Inorganic Ion Transmembrane Transport Protein Localization To Postsynapse Transmembrane Transport Monoatomic Ion Channel Activity Vacuolar Transport Monoatomic Cation Transport Trans-Golgi Network Mitotic Cleavage Furrow Ingression Pigment Granule Maturation Peptide Pheromone Maturation Chaperone-mediated Autophagy Translocation Complex Establishment Of Protein Localization