PDCD4 and RPS13

Number of citations of the paper that reports this interaction (PMID 12054647)
10

Data Source:
HPRD (two hybrid, in vitro)

		PDCD4	RPS13
Gene Name		programmed cell death 4 (neoplastic transformation inhibitor)	ribosomal protein S13
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleolus Cytosol Ribosome Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding	MRNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Cell Aging Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Negative Regulation Of RNA Splicing Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1	4 interactors: MAP3K14 NFKB2 PDCD4 SPP1
Entrez ID		27250	6207
HPRD ID		10549	01604
Ensembl ID		ENSG00000150593	ENSG00000110700
Uniprot IDs		B4DKX4 Q53EL6	P62277
PDB IDs		2GGF 2KZT 2RG8 2ZU6 3EIJ	3J3A
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process MRNA Metabolic Process Viral Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Protein Catabolic Process Amyloid Precursor Protein Catabolic Process Regulation Of Translation MRNA 3'-end Processing Cellular Response To Organic Substance Viral Transcription Regulation Of Proteolysis Translation SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum RNA 3'-end Processing Negative Regulation Of Catalytic Activity Protein Localization To Membrane Positive Regulation Of Cell Growth Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Protein Transport Regulation Of Protein Catabolic Process Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization Cellular Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Translational Termination Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Catabolic Process	NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Follicular Dendritic Cell Differentiation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of MAP Kinase Activity Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Inflammatory Response Negative Regulation Of JUN Kinase Activity Germinal Center Formation Positive Regulation Of Bone Resorption Immune System Process Regulation Of Axon Regeneration Regulation Of MAPK Cascade Regulation Of Cell Adhesion Positive Regulation Of Tissue Remodeling Decidualization Response To Vitamin D Negative Regulation Of JNK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Bone Resorption
Tagcloud ?		classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?