PDCD4 and RPL5

Number of citations of the paper that reports this interaction (PMID 12054647)
10

Data Source:
HPRD (two hybrid, in vitro)

		PDCD4	RPL5
Gene Name		programmed cell death 4 (neoplastic transformation inhibitor)	ribosomal protein L5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Cell Aging Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Height ( 20881960) Multiple sclerosis ( 19525955 17660530)
Protein-Protein Interactions		12 interactors: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1	21 interactors: CSNK2A1 CSNK2B DCC EIF5A HARS IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL PDCD4 PPM1D SPP1 SURF2 TNIP1 TNPO1 TSC22D1 UPF2 VHL
Entrez ID		27250	6125
HPRD ID		10549	04699
Ensembl ID		ENSG00000150593	ENSG00000122406
Uniprot IDs		B4DKX4 Q53EL6	A2RUM7 B3KTM6 P46777
PDB IDs		2GGF 2KZT 2RG8 2ZU6 3EIJ	3J3B
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process MRNA Metabolic Process Viral Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Protein Catabolic Process Amyloid Precursor Protein Catabolic Process Regulation Of Translation MRNA 3'-end Processing Cellular Response To Organic Substance Viral Transcription Regulation Of Proteolysis Translation SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum RNA 3'-end Processing Negative Regulation Of Catalytic Activity Protein Localization To Membrane Positive Regulation Of Cell Growth Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Protein Transport Regulation Of Protein Catabolic Process Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization Cellular Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Translational Termination Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Catabolic Process	Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Cytoplasmic Transport Protein Localization To Organelle Establishment Of Protein Localization To Organelle Negative Regulation Of Collateral Sprouting Ribosomal Protein Import Into Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Intracellular Protein Transport Cellular Protein Localization Viral Process Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Programmed Cell Death Intracellular Transport Cell Death Death Protein Import Into Nucleus, Translocation Cellular Localization Response To External Stimulus Protein Localization Protein Transport Establishment Of Localization In Cell Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Cellular Response To UV-C Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Vitamin B1 Negative Regulation Of Axonogenesis Chemotaxis MRNA Export From Nucleus Regulation Of MAPK Cascade Histidyl-tRNA Aminoacylation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury RNA Export From Nucleus Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Developmental Growth Spinal Cord Ventral Commissure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Growth Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?		classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?		classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?