PDCD4 and RPL5

Number of citations of the paper that reports this interaction (PubMedID 12054647)
0

Data Source:
HPRD (two hybrid, in vitro)

		PDCD4	RPL5
Description		programmed cell death 4	ribosomal protein L5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding RRNA Binding Ubiquitin Protein Ligase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Apoptotic Process BMP Signaling Pathway Negative Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Ribosomal Large Subunit Biogenesis Positive Regulation Of Translation Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		Fish- and plant-related diet ( 32066663)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Height ( 20881960) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 17660530 19525955)
Interacting Genes		21 interacting genes: APOE BTRC CSNK2A1 EIF4A1 EIF4A2 EIF4A3 EIF4G1 FILNC1 IBTK LRRK1 OGT PRMT5 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2 WDR77	32 interacting genes: BCAS2 CLK1 CSNK2A1 CSNK2B DCC EIF5A ERCC6 FOXP1 HARS1 IPO13 IPO5 IPO7 KPNB1 KRT31 MAP3K14 MDM2 NVL OGT PDCD4 PDE4B PPM1D RNA5S7 RNF181 SAYSD1 SPIN1 SPP1 TNIP1 TNPO1 TP73 TSC22D1 UPF2 VHL
Entrez ID		27250	6125
HPRD ID		10549	04699
Ensembl ID		ENSG00000150593	ENSG00000122406
Uniprot IDs		B4DKX4 Q53EL6	A2RUM7 P46777
PDB IDs		2GGF 2KZT 2RG8 2ZU6 3EIJ 8XXL 8XXM 8XXN 9BKD 9BLN	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8BGU 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Translation Regulation Of Primary Metabolic Process Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Translational Initiation Cytoplasmic Translational Initiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Translation Ribonucleoprotein Complex Binding Negative Regulation Of Macromolecule Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteolysis Translation Initiation Factor Activity Gamma-secretase Complex Negative Regulation Of Metabolic Process Positive Regulation Of Translation Regulation Of Wnt Signaling Pathway Negative Regulation Of Gene Expression Notch Receptor Processing Glutamatergic Synapse Amyloid-beta Formation Epithelial Cell Proliferation TORC1 Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction	Protein Localization To Organelle Protein Localization To Nucleus Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Localization Sequence Binding Cytosol Nuclear Pore Ribosomal Protein Import Into Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization To Organelle Regulation Of Signaling Negative Regulation Of Developmental Growth Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Nucleoplasm Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Proteolysis Negative Regulation Of Gene Expression Double-strand Break Repair Via Classical Nonhomologous End Joining Signal Transduction In Response To DNA Damage Small GTPase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Nucleolus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Intracellular Protein Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
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