EIF5 and NCBP2

Number of citations of the paper that reports this interaction (PubMedID 11331597)
28

Data Source:
HPRD (in vitro)

		EIF5	NCBP2
Description		eukaryotic translation initiation factor 5	nuclear cap binding protein subunit 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Cap Binding Complex RNA Cap Binding Complex Ciliary Basal Body
	Molecular Function	Nucleotide Binding RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding SnRNA Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cap-dependent Translational Initiation MRNA Processing MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translation Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing MRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II MRNA Cis Splicing, Via Spliceosome Positive Regulation Of RNA Export From Nucleus MRNA Transport
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)	Malaria ( 31844061) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		18 interacting genes: APP CDC42 CEBPA CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN OGT PUM1	7 interacting genes: DDX39B EIF4G1 EIF5 HNRNPF HNRNPH1 LZTS2 NCBP1
Entrez ID		1983	22916
HPRD ID		03417	05503
Ensembl ID		ENSG00000100664	ENSG00000114503
Uniprot IDs		P55010	F6WVI0 P52298
PDB IDs		2E9H 2G2K 2IU1 8OZ0 8PJ2 8PJ3	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG 8BY6 8PMP 8PNT 8SRR 8SUY
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translation Translation Factor Activity, RNA Binding Cap-dependent Translational Initiation Post-transcriptional Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Cytosol RNA Binding Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein Metabolic Process Viral Translational Termination-reinitiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Positive Regulation Of Growth MRNA Binding Regulation Of Synapse Organization Sin3-type Complex Translation Initiation Factor Binding Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Catabolic Process Cellular Component Assembly Regulation Of Growth Regulation Of Presynapse Organization Regulation Of Presynapse Assembly PcG Protein Complex Post-transcriptional Gene Silencing Negative Regulation Of Proteolysis Viral Process	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cap-dependent Translational Initiation RNA Binding Translational Initiation RNA Splicing Regulation Of Translational Initiation MRNA Processing Nuclear Export Spliceosomal Complex Regulation Of RNA Splicing Protein-RNA Complex Assembly MRNA Metabolic Process Cytoplasmic Translational Initiation MRNA Binding Nuclear Transport Nucleocytoplasmic Transport Spliceosomal Complex Assembly Translation Initiation Factor Activity RNA Processing MRNA Export From Nucleus Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Ribonucleoprotein Complex Positive Regulation Of RNA Binding Primary Ureteric Bud Growth Regulation Of Translation RNA Export From Nucleus Catalytic Step 2 Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Eukaryotic Initiation Factor EIF2 Binding Nucleic Acid Binding RNA Metabolic Process RNA Cap Binding Complex MRNA Transport Nuclear Cap Binding Complex Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression SnRNA Export From Nucleus RNA Transport Positive Regulation Of Cell Growth Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of MRNA 3'-end Processing Molecular Adaptor Activity Macromolecule Metabolic Process Positive Regulation Of Translation In Response To Stress 7-methylguanosine MRNA Capping ATP-dependent Protein Binding U4 SnRNA Binding
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