EIF5 and NCBP2

Number of citations of the paper that reports this interaction (PMID 11331597)
38

Data Source:
HPRD (in vitro)

		EIF5	NCBP2
Gene Name		eukaryotic translation initiation factor 5	nuclear cap binding protein subunit 2, 20kDa
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex
	Molecular Function	Translation Initiation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	Nucleotide Binding RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription 7-methylguanosine MRNA Capping MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing Gene Expression Viral Process Gene Silencing By RNA MRNA 3'-end Processing NcRNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Viral Transcription
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Tat-mediated elongation of the HIV-1 transcript Cleavage of Growing Transcript in the Termination Region Processing of Intronless Pre-mRNAs RNA Polymerase II Pre-transcription Events SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs HIV Life Cycle Transport of Mature Transcript to Cytoplasm HIV Transcription Elongation SLBP independent Processing of Histone Pre-mRNAs Nonsense-Mediated Decay (NMD) Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Capping Transport of Mature mRNAs Derived from Intronless Transcripts mRNA Splicing - Minor Pathway Metabolism of non-coding RNA mRNA Splicing - Major Pathway mRNA 3'-end processing Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) snRNP Assembly Formation of HIV elongation complex in the absence of HIV Tat Processing of Capped Intronless Pre-mRNA Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Termination Transcription of the HIV genome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		14 interactors: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 NCBP2 NRGN PUM1	7 interactors: DDX39B EIF4G1 EIF5 HNRNPF HNRNPH1 LZTS2 NCBP1
Entrez ID		1983	22916
HPRD ID		03417	05503
Ensembl ID		ENSG00000100664	ENSG00000114503
Uniprot IDs		P55010 Q6IBU0	E9PAR5 P52298
PDB IDs		2E9H 2G2K 2IU1	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY
Enriched GO Terms of Interacting Partners?		Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Gene Expression MRNA 3'-end Processing Protein Metabolic Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Macromolecular Complex Assembly Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Axon Guidance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Collateral Sprouting In Absence Of Injury Cytokine-mediated Signaling Pathway Male Germ Cell Proliferation Regulation Of Metabolic Process Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Axonogenesis Cellular Component Assembly Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis MRNA Catabolic Process Axon Choice Point Recognition Axon Development RNA Processing Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cytoplasmic Translational Initiation Positive Regulation Of Glucokinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Chemotaxis Adiponectin-activated Signaling Pathway	MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Translational Initiation RNA Splicing Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Gene Expression MRNA Export From Nucleus RNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of RNA Splicing Viral Process RNA 3'-end Processing Regulation Of Gene Expression MRNA Transport Cellular Macromolecular Complex Assembly RNA Transport RNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Cytoplasmic Transport RNA Localization RNA Secondary Structure Unwinding MRNA Catabolic Process Ribonucleoprotein Complex Assembly Negative Regulation Of DNA Damage Checkpoint RNA Catabolic Process Translational Initiation Viral MRNA Export From Host Cell Nucleus Spindle Midzone Assembly Regulation Of DNA Damage Checkpoint Microtubule Severing Ribonucleoprotein Complex Biogenesis Nucleobase-containing Compound Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MRNA 3'-end Processing Regulation Of Metabolic Process MRNA Cleavage Cellular Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process Aromatic Compound Catabolic Process
Tagcloud ?		40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic frame homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine reading similarity tagged tif35p transiently trna u20s ydr
Tagcloud (Difference) ?		40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic frame homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine reading similarity tagged tif35p transiently trna u20s ydr
Tagcloud (Intersection) ?