UBR1 and NUDT3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		UBR1	NUDT3
Gene Name		ubiquitin protein ligase E3 component n-recognin 1	nudix (nucleoside diphosphate linked moiety X)-type motif 3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytosol	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding	Magnesium Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Synthesis of pyrophosphates in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS			Body mass index ( 20935630) Height ( 19893584)
Protein-Protein Interactions		26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B	36 interactors: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1
Entrez ID		197131	11165
HPRD ID		09342	14849
Ensembl ID		ENSG00000159459
Uniprot IDs		Q8IWV7	O95989
PDB IDs		3NY1	2FVV 2Q9P
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity	Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Cellular Metabolic Process Protein Targeting Intracellular Transport Protein Localization To Organelle Cellular Localization Cellular Protein Localization Translational Elongation Establishment Of Protein Localization To Organelle Catabolic Process Protein Localization To Membrane Protein Localization Intracellular Protein Transport Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cellular Process Establishment Of Localization In Cell Protein Targeting To ER Cytoplasmic Transport Aromatic Compound Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Transport Protein Localization To Endoplasmic Reticulum DNA Strand Elongation Involved In DNA Replication Establishment Of Protein Localization Branching Involved In Mammary Gland Duct Morphogenesis DNA Strand Elongation Translational Termination Membrane Organization Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Metabolic Process MRNA Catabolic Process Transcription Factor TFIIIB Complex Assembly Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Mammary Gland Duct Morphogenesis RNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Interleukin-4 Cellular Protein Complex Disassembly Viral Life Cycle
Tagcloud ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Difference) ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Intersection) ?