UBR1 and ANXA3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	ANXA3
Description		ubiquitin protein ligase E3 component n-recognin 1	annexin A3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Nucleus Cytoplasm Plasma Membrane Vesicle Membrane Membrane Phagocytic Vesicle Membrane Specific Granule Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Calcium-dependent Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Phagocytosis Positive Regulation Of Endothelial Cell Migration Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of DNA-binding Transcription Factor Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Developmental Lineage of Pancreatic Ductal Cells
Drugs			Fluocinolone acetonide Ethanolamine Difluocortolone
Diseases		Johanson-Blizzard syndrome
GWAS		Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Daytime nap ( 33568662) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels ( 23823483) Non-albumin protein levels ( 22558069) Refractive error ( 32231278) Rheumatoid arthritis ( 22446963 30423114)
Interacting Genes		33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	6 interacting genes: EMG1 IGSF21 REG3A TP53 UBR1 UNC119
Entrez ID		197131	306
HPRD ID		09342	00111
Ensembl ID		ENSG00000159459	ENSG00000138772
Uniprot IDs		Q8IWV7	P12429
PDB IDs		3NY1 5TDC	1AII 1AXN
Enriched GO Terms of Interacting Partners?		Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Response To Symbiotic Bacterium Response To Symbiont Positive Regulation Of Detection Of Glucose Protein-folding Chaperone Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity Negative Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Protein Refolding Negative Regulation Of Protein Folding RRNA (pseudouridine) Methyltransferase Activity Nucleologenesis Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Negative Regulation Of Cellular Component Organization B Cell Lineage Commitment Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Pentose-phosphate Shunt Junctional Membrane Complex Nucleolus Organization Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of Caveolin-mediated Endocytosis L-leucine Binding
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