UBR1 and ANXA3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	ANXA3
Gene Name		ubiquitin protein ligase E3 component n-recognin 1	annexin A3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytosol	Cytoplasm Plasma Membrane Membrane Phagocytic Vesicle Membrane Specific Granule Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding	Calcium Ion Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Calcium-dependent Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine	Phagocytosis Positive Regulation Of Endothelial Cell Migration Defense Response To Bacterium Negative Regulation Of Catalytic Activity Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Non-albumin protein levels ( 22558069) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B	6 interactors: EMG1 IGSF21 REG3A TP53 UBR1 UNC119
Entrez ID		197131	306
HPRD ID		09342	00111
Ensembl ID		ENSG00000159459	ENSG00000138772
Uniprot IDs		Q8IWV7	P12429
PDB IDs		3NY1	1AII 1AXN
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity See more	Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Keratinocyte Differentiation Regulation Of Caveolin-mediated Endocytosis Mitochondrial DNA Repair Response To Leucine Positive Regulation Of Keratinocyte Proliferation Mitotic Cytokinetic Process Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Response To Light Stimulus Negative Regulation Of Epidermal Cell Differentiation ER Overload Response Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation Regulation Of Cellular Amino Acid Metabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Thymocyte Apoptotic Process RRNA Methylation Response To Radiation Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior RRNA Modification Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Cell Separation After Cytokinesis Rhythmic Behavior Lipoprotein Transport Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator See more
Tagcloud ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated	1e 3e 7e accessed adam28 adenocarcinomas cabig cadm1 ccne1 cd24 cdk1 cdkn2a com datasets demonstration ercc1 geo kmplot logrank online opn plot plotted rad51 repositories silico tcga uni www
Tagcloud (Difference) ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated	1e 3e 7e accessed adam28 adenocarcinomas cabig cadm1 ccne1 cd24 cdk1 cdkn2a com datasets demonstration ercc1 geo kmplot logrank online opn plot plotted rad51 repositories silico tcga uni www
Tagcloud (Intersection) ?