UBR1 and TAC3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	TAC3
Gene Name		ubiquitin protein ligase E3 component n-recognin 1	tachykinin 3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytosol	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding	Receptor Binding Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine	Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B	10 interactors: CCDC90B FEZ1 GPRASP1 IKBKAP PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		197131	6866
HPRD ID		09342	08877
Ensembl ID		ENSG00000159459	ENSG00000166863
Uniprot IDs		Q8IWV7	Q9UHF0
PDB IDs		3NY1	1P9F
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity	Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Operant Conditioning Neuropeptide Signaling Pathway Positive Regulation Of Vascular Permeability Learning Regulation Of Muscle Contraction Regulation Of Vascular Permeability Positive Regulation Of Blood Pressure Response To Morphine Learning Or Memory Response To Electrical Stimulus Excretion Cognition Blood Circulation Smooth Muscle Contraction Cellular Response To Stimulus Positive Regulation Of Acetylcholine Secretion, Neurotransmission Response To Abiotic Stimulus Single-organism Behavior Response To Ammonium Ion Negative Regulation Of Signaling Cellular Response To Leucine G-protein Coupled Receptor Catabolic Process Positive Regulation Of Synaptic Transmission Response To Estradiol Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Smooth Muscle Contraction Involved In Micturition Synaptic Transmission Behavior Response To Organic Substance Response To Stimulus Response To Alkaloid Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Saliva Secretion Regulation Of Blood Pressure Regulation Of Cellular Process Prolactin Secretion Negative Regulation Of Gonadotropin Secretion Regulation Of Synaptic Transmission, Cholinergic Response To Leucine Regulation Of Saliva Secretion Micturition Response To Ozone Endosomal Transport
Tagcloud ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated	bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Difference) ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated	bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Intersection) ?