UBR1 and ARL4D

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	ARL4D
Description		ubiquitin protein ligase E3 component n-recognin 1	ARF like GTPase 4D
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Intracellular Protein Transport Protein Secretion Vesicle-mediated Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Johanson-Blizzard syndrome
GWAS		Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	22 interacting genes: APP ARL6IP1 CCDC102B CNPY4 CYTH2 DNAJA1 EIF2B1 EML4 EPRS1 MAPK8IP3 NDRG1 PGAM1 PRKCSH SMAD1 SMAD2 SMURF1 SNRPN TGFBR1 TLE1 TMEM230 UBR1 UNC119
Entrez ID		197131	379
HPRD ID		09342	02842
Ensembl ID		ENSG00000159459	ENSG00000175906
Uniprot IDs		Q8IWV7	P49703
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?		Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	I-SMAD Binding Homomeric SMAD Protein Complex SMAD Protein Complex SMAD Binding Trophoblast Cell Migration Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Co-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Axo-dendritic Transport Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Response To Growth Factor Protein Serine/threonine Kinase Binding Cytosol Cytoplasm Ubiquitin Protein Ligase Binding SMAD Protein Signal Transduction Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Response To Cholesterol R-SMAD Binding Growth Cone Regulation Of JNK Cascade MiRNA Processing Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Proline-tRNA Ligase Activity Prolyl-tRNA Aminoacylation Ureteric Bud Development Engulfment Of Target By Autophagosome Transport Along Microtubule
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