UBR1 and PLIN2

Number of citations of the paper that reports this interaction (PubMedID 37057345)
38

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		UBR1	PLIN2
Description		ubiquitin protein ligase E3 component n-recognin 1	perilipin 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Response To Xenobiotic Stimulus Positive Regulation Of Triglyceride Storage Long-chain Fatty Acid Transport Lipid Storage Cellular Response To Glucose Starvation Lipid Droplet Disassembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Johanson-Blizzard syndrome
GWAS		Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Abdominal aortic calcification levels ( 31659325) Systolic blood pressure ( 30578418)
Interacting Genes		33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	9 interacting genes: ABHD5 ARF1 DESI2 HTATIP2 MAPK10 OGT POGZ SFT2D2 UBR1
Entrez ID		197131	123
HPRD ID		09342	00057
Ensembl ID		ENSG00000159459	ENSG00000147872
Uniprot IDs		Q8IWV7	Q6FHZ7 Q99541
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?		Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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