UBR1 and LAMTOR3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		UBR1	LAMTOR3
Gene Name		ubiquitin protein ligase E3 component n-recognin 1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytosol	Focal Adhesion Extracellular Vesicular Exosome Ragulator Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Complex Scaffold
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine	Positive Regulation Of TOR Signaling Cellular Protein Localization Positive Regulation Of GTPase Activity Cellular Response To Amino Acid Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B	16 interactors: ADAMTS10 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS SUFU UBR1
Entrez ID		197131	8649
HPRD ID		09342	04485
Ensembl ID		ENSG00000159459	ENSG00000109270
Uniprot IDs		Q8IWV7	Q9UHA4
PDB IDs		3NY1	1SKO 2ZL1 3CPT
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity	Regulation Of Golgi Inheritance Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Activation Of MAPKK Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase Activity Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Transport Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction MAPK Cascade Neurotrophin Signaling Pathway Positive Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Innate Immune Response
Tagcloud ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Difference) ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Intersection) ?