UBR1 and ARL3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	ARL3
Description		ubiquitin protein ligase E3 component n-recognin 1	ARF like GTPase 3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Cytoskeleton Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Membrane Midbody Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Mitotic Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Smoothened Signaling Pathway Small GTPase-mediated Signal Transduction Protein Transport Intraciliary Transport Photoreceptor Cell Development Cell Division Cilium Assembly Protein Localization To Cilium Protein Localization To Ciliary Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Trafficking of myristoylated proteins to the cilium
Drugs			2-(N-morpholino)ethanesulfonic acid Guanosine-5'-Diphosphate
Diseases		Johanson-Blizzard syndrome
GWAS		Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 30487518) Mean arterial pressure (long-term average) ( 28348047) Prostate cancer ( 23535732) Pulse pressure ( 30487518) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 27922604) Systolic blood pressure ( 30487518) Systolic blood pressure (long-term average) ( 28348047) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	12 interacting genes: ARL2BP GOLGA4 LRIF1 PDE6D RP2 TBL1X TLE1 TMEM132D TP53 TUBA1A UBR1 UNC119
Entrez ID		197131	403
HPRD ID		09342	05260
Ensembl ID		ENSG00000159459	ENSG00000138175
Uniprot IDs		Q8IWV7	P36405
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?		Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Nervous System Process Forebrain Morphogenesis Circadian Behavior Rhythmic Behavior Dentate Gyrus Development Cilium Sensory Perception Visual Perception System Process Sensory Perception Of Light Stimulus Regulation Of Cellular Senescence Regulation Of Phosphorus Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Protein Stabilization Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Transport
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