EFNA1 and EEF1G

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EFNA1	EEF1G
Gene Name		ephrin-A1	eukaryotic translation elongation factor 1 gamma
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding Ephrin Receptor Binding	Translation Elongation Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Negative Regulation Of Dendritic Spine Morphogenesis	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Translation Eukaryotic Translation Elongation
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732)
Protein-Protein Interactions		14 interactors: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6	87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24
Entrez ID		1942	1937
HPRD ID		01858	11745
Ensembl ID		ENSG00000169242	ENSG00000254772
Uniprot IDs		P20827	P26641 Q53YD7
PDB IDs		3CZU 3HEI 3MBW	1PBU
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Peptidyl-tyrosine Phosphorylation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Locomotion Cell Part Morphogenesis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Generation Of Neurons Neuron Differentiation Neurogenesis Cell Projection Organization Protein Phosphorylation Nervous System Development Cell Development Phosphorylation Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Anatomical Structure Morphogenesis Cellular Protein Metabolic Process Cell Differentiation Regulation Of Rac GTPase Activity Fasciculation Of Motor Neuron Axon Regulation Of Rho GTPase Activity Response To Stimulus Phosphate-containing Compound Metabolic Process Cellular Response To Stimulus Regulation Of Cell Adhesion Signal Transduction Regulation Of Rac Protein Signal Transduction Fasciculation Of Sensory Neuron Axon Regulation Of Rho Protein Signal Transduction System Development Protein Metabolic Process Regulation Of Intracellular Signal Transduction Signaling Cell Communication Multicellular Organismal Development	Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity
Tagcloud ?		abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Difference) ?		abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Intersection) ?