EFNA1 and EPHA8

Number of citations of the paper that reports this interaction (PubMedID 10515610)
0

Data Source:
HPRD (in vitro)

		EFNA1	EPHA8
Description		ephrin A1	EPH receptor A8
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane	Endosome Plasma Membrane Membrane Dendrite Early Endosome Membrane Cell Projection Neuron Projection
	Molecular Function	Signaling Receptor Binding Protein Binding Ephrin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Growth Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Central Nervous System Neuron Differentiation Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Biological Quality Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process	Substrate-dependent Cell Migration Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Neuron Remodeling Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emotional recognition ( 31596458) Gamma glutamyl transferase levels ( 33339817) Inflammatory bowel disease ( 28067908) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Urinary albumin excretion ( 30220432)	Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		15 interacting genes: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 HUNK KAT5 PPBP XRCC6	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		1942	2046
HPRD ID		01858	01493
Ensembl ID		ENSG00000169242	ENSG00000070886
Uniprot IDs		P20827	P29322
PDB IDs		3CZU 3HEI 3MBW	1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Kinase Activity Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Enzyme-linked Receptor Protein Signaling Pathway Dendrite ATP Binding Nucleotide Binding Transferase Activity Neuron Projection Development Regulation Of Cell Adhesion Signal Transduction Fasciculation Of Motor Neuron Axon Cell Surface Receptor Signaling Pathway Fasciculation Of Sensory Neuron Axon Plasma Membrane Bounded Cell Projection Organization Regulation Of GTPase Activity Growth Factor Binding Regulation Of Multicellular Organismal Development Nephric Duct Morphogenesis Cell Projection Organization Axon Guidance Receptor Activity Cell Adhesion Regulation Of Cell Junction Assembly Regulation Of Developmental Process Cell Migration Regulation Of Cellular Component Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Catalytic Activity Nervous System Development Regulation Of Synapse Organization Axonal Fasciculation Neuron Projection Fasciculation Retinal Ganglion Cell Axon Guidance Cell Recognition Chemotaxis System Development Cell Motility Central Nervous System Projection Neuron Axonogenesis Regulation Of MAPK Cascade Locomotion Regulation Of Postsynapse Organization Ephrin Receptor Binding	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway ATP Binding Neuron Projection Guidance Axon Guidance Nucleotide Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Synapse Organization Side Of Membrane Signaling Receptor Binding Regulation Of Postsynapse Organization Synaptic Membrane Adhesion Regulation Of Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Organization Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Regulation Of Cell Morphogenesis Cellular Response To Glycine Response To Singlet Oxygen Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Modification Process Positive Regulation Of Synapse Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Nucleoside Triphosphate Adenylate Kinase Activity Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Phosphate Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Proliferation Response To Glycine Nuclear Proteasome Complex DNA/RNA Helicase Activity Aspartyl-tRNA Aminoacylation
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