EFNA1 and EPHA6

Number of citations of the paper that reports this interaction (PMID 8755474)
133

Data Source:
HPRD (in vitro)

		EFNA1	EPHA6
Gene Name		ephrin-A1	EPH receptor A6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome	Cellular_component Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Protein Binding Ephrin Receptor Binding	Molecular_function Ephrin Receptor Activity ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Negative Regulation Of Dendritic Spine Morphogenesis	Axon Guidance Biological_process Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732)	Blood trace element (Cu levels) ( 23720494) Blood trace element (Zn levels) ( 23720494) Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6	2 interactors: EFNA1 EFNA4
Entrez ID		1942	285220
HPRD ID		01858	13275
Ensembl ID		ENSG00000169242	ENSG00000080224
Uniprot IDs		P20827	B3KS12 D6RAL5 Q6UWM0 Q9UF33
PDB IDs		3CZU 3HEI 3MBW
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Peptidyl-tyrosine Phosphorylation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Locomotion Cell Part Morphogenesis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Generation Of Neurons Neuron Differentiation Neurogenesis Cell Projection Organization Protein Phosphorylation Nervous System Development Cell Development Phosphorylation Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Anatomical Structure Morphogenesis Cellular Protein Metabolic Process Cell Differentiation Regulation Of Rac GTPase Activity Fasciculation Of Motor Neuron Axon Regulation Of Rho GTPase Activity Response To Stimulus Phosphate-containing Compound Metabolic Process Cellular Response To Stimulus Regulation Of Cell Adhesion Signal Transduction Regulation Of Rac Protein Signal Transduction Fasciculation Of Sensory Neuron Axon Regulation Of Rho Protein Signal Transduction System Development Protein Metabolic Process Regulation Of Intracellular Signal Transduction Signaling Cell Communication Multicellular Organismal Development	Ephrin Receptor Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Axon Guidance Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Axonogenesis Mitral Valve Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Negative Regulation Of Dendrite Morphogenesis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Notochord Morphogenesis Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Dendrite Development Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Heart Valve Formation Cell-cell Signaling Negative Regulation Of Epithelial To Mesenchymal Transition Neuron Development Atrioventricular Valve Morphogenesis Notochord Development Atrioventricular Valve Development Cell Morphogenesis Cardiac Epithelial To Mesenchymal Transition Neuron Differentiation Cell Projection Organization Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Stem Cell Differentiation Locomotion Heart Valve Morphogenesis Heart Valve Development Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Osteoclast Differentiation Regulation Of Blood Vessel Endothelial Cell Migration Movement Of Cell Or Subcellular Component Regulation Of Dendritic Spine Development Generation Of Neurons Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Bone Remodeling
Tagcloud ?		abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217	a2bp1 abat cdh2 chmp2b cnvs crmp1 dementias dmrt1 duplications encompassing eo epha5 ermp1 evc evc2 fad flj35024 mapt microarrays pathogenicity pedigrees penetrant perhaps presenilin private psen1 psen2 underlie vldlr
Tagcloud (Difference) ?		abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217	a2bp1 abat cdh2 chmp2b cnvs crmp1 dementias dmrt1 duplications encompassing eo epha5 ermp1 evc evc2 fad flj35024 mapt microarrays pathogenicity pedigrees penetrant perhaps presenilin private psen1 psen2 underlie vldlr
Tagcloud (Intersection) ?