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NR0B1 and NR5A1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid, in vitro)
NR0B1
NR5A1
Description
nuclear receptor subfamily 0 group B member 1
nuclear receptor subfamily 5 group A member 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Ribosome
Membrane
Nuclear Speck
Centriolar Satellite
Chromatin
Nucleus
Nucleoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleic Acid Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
Nuclear Receptor Binding
Protein Domain Specific Binding
DNA Hairpin Binding
Protein Homodimerization Activity
AF-2 Domain Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Phospholipid Binding
Zinc Ion Binding
Lipid Binding
Enzyme Binding
Sequence-specific DNA Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Developmental Process Involved In Reproduction
Spermatogenesis
Sex Determination
Intracellular Protein Localization
Gonad Development
Male Gonad Development
Negative Regulation Of Steroid Biosynthetic Process
Hypothalamus Development
Pituitary Gland Development
Male Sex Determination
Adrenal Gland Development
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Leydig Cell Differentiation
Response To Immobilization Stress
Endodermal Cell Differentiation
Negative Regulation Of Gluconeogenesis
Negative Regulation Of DNA-templated Transcription
Sertoli Cell Differentiation
Luteinization
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Sex Determination
Primary Sex Determination
Male Gonad Development
Female Gonad Development
Hormone-mediated Signaling Pathway
Tissue Development
Positive Regulation Of Gene Expression
Male Sex Determination
Adrenal Gland Development
Intracellular Receptor Signaling Pathway
Leydig Cell Differentiation
Hormone Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Steroid Biosynthetic Process
Maintenance Of Protein Location In Nucleus
Sertoli Cell Differentiation
Response To Gonadotropin-releasing Hormone
Calcineurin-mediated Signaling
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation of testis differentiation
Drugs
Dexamethasone
Dexamethasone acetate
(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE
Phosphatidyl ethanol
Diseases
Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
Premature ovarian failure
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Chronotype (
30696823
)
Interacting Genes
17 interacting genes:
AR
COPS2
EEF2KMT
ESR1
ESR2
ESRRA
ESRRG
NR3C1
NR5A1
NRIP1
PGR
POU5F1
PPARG
RNF31
RORA
SNW1
SREBF1
35 interacting genes:
AR
CATSPERT
CKS1B
CREBBP
CTNNB1
CXXC1
EDF1
GATA4
GTF2B
JUN
MAPK1
NCK2
NCOA1
NFKB2
NFYA
NR0B1
NRIP1
NTAQ1
PIAS1
PITX1
PNRC2
PROX1
RAD54L2
RFC5
SMARCD3
SOX2
SOX8
SOX9
SP1
TBX19
TEKT4
TRAPPC2
TRERF1
UBE2I
ZNF653
Entrez ID
190
2516
HPRD ID
08362
01702
Ensembl ID
ENSG00000169297
ENSG00000136931
Uniprot IDs
F1D8P4
P51843
F1D8R8
Q13285
PDB IDs
4RWV
1YOW
1ZDT
4QJR
4QK4
7KHT
8DAF
Enriched GO Terms of Interacting Partners
?
Nuclear Receptor Activity
Estrogen Response Element Binding
Intracellular Receptor Signaling Pathway
Hormone-mediated Signaling Pathway
Nuclear Receptor-mediated Signaling Pathway
Steroid Binding
Sequence-specific DNA Binding
Nuclear Steroid Receptor Activity
DNA-binding Transcription Factor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of RNA Metabolic Process
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of MiRNA Transcription
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Metabolic Process
Intracellular Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Coregulator Binding
Sequence-specific Double-stranded DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Rhythmic Process
Positive Regulation Of Metabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Lipid
Negative Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Response To Lipid
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
DNA Binding
Cellular Response To Oxygen-containing Compound
Enzyme Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Nucleus
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nuclear Receptor Binding
Regulation Of Gene Expression
Nucleoplasm
Negative Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Transcription Cis-regulatory Region Binding
Cell Fate Commitment
DNA-binding Transcription Factor Binding
Gland Development
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Negative Regulation Of Macromolecule Biosynthetic Process
Male Gonad Development
Negative Regulation Of Biosynthetic Process
Reproductive Structure Development
Sequence-specific Double-stranded DNA Binding
Transcription Coregulator Activity
RNA Polymerase II Transcription Regulator Complex
Gonad Development
Animal Organ Development
Pituitary Gland Development
Glial Cell Fate Commitment
Developmental Induction
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