NR5A1 and SOX8

Number of citations of the paper that reports this interaction (PMID 12732652)
22

Data Source:
HPRD (in vitro)

		NR5A1	SOX8
Gene Name		nuclear receptor subfamily 5, group A, member 1	SRY (sex determining region Y)-box 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Factor Binding Protein Heterodimerization Activity
	Biological Process	Luteinization Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Primary Sex Determination Male Gonad Development Tissue Development Multicellular Organismal Aging Gene Expression Cell Differentiation Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		28 interactors: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRERF1 ZNF653	18 interactors: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		2516	30812
HPRD ID		01702	16175
Ensembl ID		ENSG00000136931	ENSG00000005513
Uniprot IDs		F1D8R8 Q13285	P57073
PDB IDs		1YOW 1ZDT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Reproductive Structure Development Reproductive System Development Sex Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation Developmental Process Involved In Reproduction Multicellular Organismal Development Androgen Receptor Signaling Pathway Cell Fate Commitment Embryonic Morphogenesis Male Sex Differentiation Rhythmic Process Cell Differentiation Organ Development Single Organism Reproductive Process Regulation Of Cellular Process Glial Cell Fate Commitment Camera-type Eye Morphogenesis Developmental Process Anatomical Structure Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Cell Differentiation Tissue Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Liver Development Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Embryonic Organ Development Positive Regulation By Host Of Viral Transcription Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Heart Development Endoderm Development
Tagcloud ?		attracted bisphenol bpa durations esr estrogenic expressions flanking gobiocypris inhibitive involve minnow monomer mug nominal obviously oocyte ovarian ovary rarus reproduction researchers steroidogenesis steroidogenic stimulative subfamily suppressive vitellogenin vtg	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Difference) ?		attracted bisphenol bpa durations esr estrogenic expressions flanking gobiocypris inhibitive involve minnow monomer mug nominal obviously oocyte ovarian ovary rarus reproduction researchers steroidogenesis steroidogenic stimulative subfamily suppressive vitellogenin vtg	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Intersection) ?