NR0B1 and RNF31

Number of citations of the paper that reports this interaction (PubMedID 19237537)
53

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NR0B1	RNF31
Description		nuclear receptor subfamily 0 group B member 1	ring finger protein 31
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Ribosome Membrane Nuclear Speck Centriolar Satellite	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding DNA Hairpin Binding Protein Homodimerization Activity AF-2 Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Developmental Process Involved In Reproduction Spermatogenesis Sex Determination Intracellular Protein Localization Gonad Development Male Gonad Development Negative Regulation Of Steroid Biosynthetic Process Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Endodermal Cell Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of DNA-templated Transcription Sertoli Cell Differentiation	Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Ubiquitination CD40 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Xenophagy
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway
Drugs		Dexamethasone Dexamethasone acetate
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Suicide behavior ( 26079190)
Interacting Genes		17 interacting genes: AR COPS2 EEF2KMT ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1	60 interacting genes: ACVRL1 AGO2 ATG13 ATN1 ATXN1 ATXN7 AZI2 CASP1 CASP6 CASP8 CCDC24 CDC34 GFI1B GPX4 HDAC6 IKBKG KIF1A KRTAP9-2 MECOM NOS3 NR0B1 NR0B2 PINK1 PITX1 PRKCA PTEN RBCK1 RNF26 SEPTIN2 SHARPIN SMAD3 SNRPC SOCS3 STAT3 STK4 TLE5 TNF TRAF1 TRAF6 TRIM25 TSSC4 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2T UBE2W VASN VDAC1
Entrez ID		190	55072
HPRD ID		08362	11516
Ensembl ID		ENSG00000169297	ENSG00000092098
Uniprot IDs		F1D8P4 P51843	Q96EP0
PDB IDs		4RWV	2CT7 4DBG 4JUY 4LJO 4LJP 4LJQ 4OWF 4OYJ 4OYK 4P09 4P0A 4P0B 5EDV 5LJN 5X0W 6GZY 6KC5 6KC6 6SC5 6SC6 6SC7 6SC8 6SC9 7TV4 7UY2 7UYJ 7UYK 7V8F 7V8G 8Z30 8Z36 9AZJ 9B0B 9B0Z 9B12
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Estrogen Response Element Binding Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Steroid Binding Sequence-specific DNA Binding Nuclear Steroid Receptor Activity DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Lipid Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Response To Lipid Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process DNA Binding Cellular Response To Oxygen-containing Compound Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Transferase Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process ATP Binding Nucleotide Binding Regulation Of Canonical NF-kappaB Signal Transduction Nucleus Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Cytosol Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Protein-containing Complex Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication
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