NR0B1 and RORA

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		NR0B1	RORA
Gene Name		nuclear receptor subfamily 0, group B, member 1	RAR-related orphan receptor A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Polysomal Ribosome	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Transcription Corepressor Activity RNA Binding Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding DNA Hairpin Binding Steroid Hormone Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding AF-2 Domain Binding	Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Steroid Biosynthetic Process Spermatogenesis Protein Localization Gonad Development Male Gonad Development Gene Expression Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Sertoli Cell Differentiation	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Circadian Rhythm Regulation Of Smoothened Signaling Pathway Gene Expression Positive Regulation Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Hypoxia T-helper 17 Cell Differentiation Regulation Of Cholesterol Homeostasis
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs		Tretinoin Dexamethasone
Diseases
GWAS			Asthma ( 20860503) Breast cancer (prognosis) ( 23319801) C-reactive protein ( 21300955) Depression (quantitative trait) ( 20800221) Gamma gluatamyl transferase levels ( 22010049) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Menarche (age at onset) ( 21102462 23599027) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume ( 21116278)
Protein-Protein Interactions		16 interactors: AR COPS2 ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1	20 interactors: COPS5 EIF3I EP300 GFAP LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 ZXDC
Entrez ID		190	6095
HPRD ID		08362	02896
Ensembl ID			ENSG00000069667
Uniprot IDs		F1D8P4 P51843	F1DAL0 P35398
PDB IDs			1N83 1S0X
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Lipid Cellular Response To Steroid Hormone Stimulus Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Lipid Cellular Response To Organic Cyclic Compound Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Response To Hormone RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Cellular Response To Organic Substance Signaling Positive Regulation Of Cellular Metabolic Process Cell Communication Nucleobase-containing Compound Metabolic Process Rhythmic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus System Development Response To Organic Substance Ovulation Cycle Process Nitrogen Compound Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Cellular Metabolic Process Limbic System Development Peptidyl-lysine Modification Response To Steroid Hormone Regulation Of Cell Differentiation Histone Acetylation Positive Regulation Of Cell Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Cell Development Protein Acetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Chromatin Modification Response To Hormone Positive Regulation Of Epithelial Cell Proliferation Histone H4 Acetylation Histone Modification Regulation Of Neurogenesis
Tagcloud ?		always cd99 chondrosarcoma comprising differentiate diffuse e2f3 es ewing ewsr1 exceptional extraskeletal fli1 gold immunohistochemical marker merkel mesenchymal myxoid neoplasm neuroblastomas nkx2 olfactory powerful reinforces round sarcoma singly srcts	15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique
Tagcloud (Difference) ?		always cd99 chondrosarcoma comprising differentiate diffuse e2f3 es ewing ewsr1 exceptional extraskeletal fli1 gold immunohistochemical marker merkel mesenchymal myxoid neoplasm neuroblastomas nkx2 olfactory powerful reinforces round sarcoma singly srcts	15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique
Tagcloud (Intersection) ?