NR5A1 and SOX9

Number of citations of the paper that reports this interaction (PMID 9774680)
70

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NR5A1	SOX9
Gene Name		nuclear receptor subfamily 5, group A, member 1	SRY (sex determining region Y)-box 9
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Protein Complex Nuclear Transcription Factor Complex
	Molecular Function	DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding	Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase Activity Protein Binding Beta-catenin Binding Protein Kinase A Catalytic Subunit Binding Enhancer Binding BHLH Transcription Factor Binding Protein Heterodimerization Activity Pre-mRNA Intronic Binding
	Biological Process	Luteinization Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Primary Sex Determination Male Gonad Development Tissue Development Multicellular Organismal Aging Gene Expression Cell Differentiation Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Skeletal System Development Cartilage Condensation Ossification Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Epithelial To Mesenchymal Transition Tissue Homeostasis Positive Regulation Of Protein Phosphorylation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Immune System Process Heart Valve Development Heart Valve Morphogenesis Heart Valve Formation Endocardial Cushion Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Chondrocyte Hypertrophy Nucleosome Assembly Chromatin Remodeling Transcription From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Cytoskeleton Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Positive Regulation Of Cell Proliferation Male Gonad Development Regulation Of Cell Cycle Process Positive Regulation Of Epithelial Cell Migration Neural Crest Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Male Germ-line Sex Determination CAMP-mediated Signaling Regulation Of Cell Adhesion Extracellular Matrix Organization Negative Regulation Of Ossification Negative Regulation Of Bone Mineralization Prostate Gland Development Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Mammary Gland Development Notochord Development Otic Vesicle Formation Endocrine Pancreas Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Somatic Stem Cell Maintenance Intrahepatic Bile Duct Development Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Myoblast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Sertoli Cell Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Limb Bud Formation Retinal Rod Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Intestinal Epithelial Structure Maintenance Regulation Of Cell Proliferation Involved In Tissue Homeostasis Positive Regulation Of Cartilage Development Regulation Of Branching Involved In Lung Morphogenesis Morphogenesis Of A Branching Epithelium Negative Regulation Of Biomineral Tissue Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Interleukin-1 Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Induction Ureter Urothelium Development Ureter Smooth Muscle Cell Differentiation Ureter Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Male Gonad Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Pulmonary function (interaction) ( 23284291) Pulmonary function decline ( 22424883) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		28 interactors: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRERF1 ZNF653	14 interactors: ATP6V1H CREB1 CREB3L4 CREBBP EP300 HERC1 HSPA1A KPNB1 MAF MED12 NR5A1 RUNX2 SPEN TRAF2
Entrez ID		2516	6662
HPRD ID		01702	06427
Ensembl ID		ENSG00000136931	ENSG00000125398
Uniprot IDs		F1D8R8 Q13285	P48436
PDB IDs		1YOW 1ZDT	1S9M 1SX9 4EUW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Reproductive Structure Development Reproductive System Development Sex Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation Developmental Process Involved In Reproduction Multicellular Organismal Development Androgen Receptor Signaling Pathway Cell Fate Commitment Embryonic Morphogenesis Male Sex Differentiation Rhythmic Process Cell Differentiation Organ Development Single Organism Reproductive Process Regulation Of Cellular Process Glial Cell Fate Commitment Camera-type Eye Morphogenesis Developmental Process Anatomical Structure Development	Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated Notch Signaling Pathway RNA Metabolic Process RNA Biosynthetic Process Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Gene Expression Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Heat DNA-templated Transcription, Initiation Cellular Response To Stimulus Signal Transduction Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Stabilization Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Signaling Rhythmic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Response To Heat Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Unfolded Protein
Tagcloud ?		attracted bisphenol bpa durations esr estrogenic expressions flanking gobiocypris inhibitive involve minnow monomer mug nominal obviously oocyte ovarian ovary rarus reproduction researchers steroidogenesis steroidogenic stimulative subfamily suppressive vitellogenin vtg	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Difference) ?		attracted bisphenol bpa durations esr estrogenic expressions flanking gobiocypris inhibitive involve minnow monomer mug nominal obviously oocyte ovarian ovary rarus reproduction researchers steroidogenesis steroidogenic stimulative subfamily suppressive vitellogenin vtg	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Intersection) ?