NR0B1 and COPS2

Number of citations of the paper that reports this interaction (PubMedID 10713076)
0

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		NR0B1	COPS2
Description		nuclear receptor subfamily 0 group B member 1	COP9 signalosome subunit 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Ribosome Membrane Nuclear Speck Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding DNA Hairpin Binding Protein Homodimerization Activity AF-2 Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Developmental Process Involved In Reproduction Spermatogenesis Sex Determination Intracellular Protein Localization Gonad Development Male Gonad Development Negative Regulation Of Steroid Biosynthetic Process Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Endodermal Cell Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of DNA-templated Transcription Sertoli Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Protein Neddylation Negative Regulation Of DNA-templated Transcription Regulation Of Protein Neddylation
Pathways			DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs		Dexamethasone Dexamethasone acetate
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		17 interacting genes: AR COPS2 EEF2KMT ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1	39 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL4A CUL5 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 UBC VDR ZNF446
Entrez ID		190	9318
HPRD ID		08362	05146
Ensembl ID		ENSG00000169297	ENSG00000166200
Uniprot IDs		F1D8P4 P51843	P61201 Q59EL2
PDB IDs		4RWV	4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Estrogen Response Element Binding Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Steroid Binding Sequence-specific DNA Binding Nuclear Steroid Receptor Activity DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Lipid Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Response To Lipid Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process DNA Binding Cellular Response To Oxygen-containing Compound Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Nucleoplasm Sin3-type Complex Negative Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Removal Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nuclear Receptor Activity MRNA Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Chromatin Regulation Of Post-translational Protein Modification MRNA Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Histone Deacetylase Regulator Activity Positive Regulation Of RNA Metabolic Process Post-translational Protein Modification Regulation Of Thyroid Hormone Receptor Signaling Pathway DeNEDDylase Activity Negative Regulation Of Stem Cell Population Maintenance Retinoic Acid-responsive Element Binding Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Protein Metabolic Process Regulation Of Protein Modification Process Cytosol
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