NR5A1 and CXXC1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		NR5A1	CXXC1
Gene Name		nuclear receptor subfamily 5, group A, member 1	CXXC finger protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding	Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding
	Biological Process	Luteinization Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Primary Sex Determination Male Gonad Development Tissue Development Multicellular Organismal Aging Gene Expression Cell Differentiation Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation
Pathways		Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Nuclear Receptor transcription pathway	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 20062064)
Protein-Protein Interactions		28 interactors: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRERF1 ZNF653	8 interactors: EP300 MEOX2 NR5A1 PPP1CA SMURF1 TAX1BP1 TBP TP53
Entrez ID		2516	30827
HPRD ID		01702	10852
Ensembl ID		ENSG00000136931	ENSG00000154832
Uniprot IDs		F1D8R8 Q13285	Q9P0U4
PDB IDs		1YOW 1ZDT	3QMB 3QMC 3QMD 3QMG 3QMH 3QMI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Reproductive Structure Development Reproductive System Development Sex Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation Developmental Process Involved In Reproduction Multicellular Organismal Development Androgen Receptor Signaling Pathway Cell Fate Commitment Embryonic Morphogenesis Male Sex Differentiation Rhythmic Process Cell Differentiation Organ Development Single Organism Reproductive Process Regulation Of Cellular Process Glial Cell Fate Commitment Camera-type Eye Morphogenesis Developmental Process Anatomical Structure Development	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Rhythmic Process Somitogenesis Somite Development Regulation Of Gene Expression Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Segmentation Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Photoperiodism Entrainment Of Circadian Clock Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Aging Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Deacetylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Epithelium Development Histone H2B Acetylation Transcription, DNA-templated Pattern Specification Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage RNA Biosynthetic Process Regulation Of Circadian Rhythm Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels
Tagcloud ?		attracted bisphenol bpa durations esr estrogenic expressions flanking gobiocypris inhibitive involve minnow monomer mug nominal obviously oocyte ovarian ovary rarus reproduction researchers steroidogenesis steroidogenic stimulative subfamily suppressive vitellogenin vtg	accessibility cfp cfp1 cg cpg cpgs dense dinucleotides elegans genomes h3k4me3 hot invertebrates irrelevant islands lie nonmethylated occupied ortholog promoters recruits remainder set1 setd1a sparsely unmethylated unusually vertebrate
Tagcloud (Difference) ?		attracted bisphenol bpa durations esr estrogenic expressions flanking gobiocypris inhibitive involve minnow monomer mug nominal obviously oocyte ovarian ovary rarus reproduction researchers steroidogenesis steroidogenic stimulative subfamily suppressive vitellogenin vtg	accessibility cfp cfp1 cg cpg cpgs dense dinucleotides elegans genomes h3k4me3 hot invertebrates irrelevant islands lie nonmethylated occupied ortholog promoters recruits remainder set1 setd1a sparsely unmethylated unusually vertebrate
Tagcloud (Intersection) ?