NR0B1 and POU5F1

Number of citations of the paper that reports this interaction (PubMedID 19528230)
38

Data Source:
BioGRID (pull down)

		NR0B1	POU5F1
Description		nuclear receptor subfamily 0 group B member 1	POU class 5 homeobox 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Ribosome Membrane Nuclear Speck Centriolar Satellite	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding DNA Hairpin Binding Protein Homodimerization Activity AF-2 Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Developmental Process Involved In Reproduction Spermatogenesis Sex Determination Intracellular Protein Localization Gonad Development Male Gonad Development Negative Regulation Of Steroid Biosynthetic Process Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Endodermal Cell Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of DNA-templated Transcription Sertoli Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Blastocyst Development Heart Induction Endodermal-mesodermal Cell Signaling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression BMP Signaling Pathway Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Cell Fate Determination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of MiRNA Transcription
Pathways			POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Germ layer formation at gastrulation Formation of the anterior neural plate Specification of primordial germ cells Specification of the neural plate border
Drugs		Dexamethasone Dexamethasone acetate
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cold sores ( 28928442) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21801394) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lung cancer ( 31577861) Lymphocyte count ( 27863252) Malaria ( 31844061) Multiple myeloma ( 23955597) Night sleep phenotypes ( 27126917) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Type 2 diabetes ( 28869590 30718926 24509480) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: AR COPS2 EEF2KMT ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1	15 interacting genes: AR CFTR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH LRRK2 MNAT1 NR0B1 SOX10 SOX2 SOX8 WDR5
Entrez ID		190	5460
HPRD ID		08362	01252
Ensembl ID		ENSG00000169297	ENSG00000204531
Uniprot IDs		F1D8P4 P51843	D2IYK3 F2Z381 M1S623 Q01860
PDB IDs		4RWV	6T90 6YOV 7U0G 7U0I 8G87 8G88 8G8B 8G8E 8G8G 8OTS 8SPS 8SPU
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Estrogen Response Element Binding Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Steroid Binding Sequence-specific DNA Binding Nuclear Steroid Receptor Activity DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Lipid Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Response To Lipid Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process DNA Binding Cellular Response To Oxygen-containing Compound Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Chromatin Regulation Of Macromolecule Metabolic Process Male Gonad Development Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Gonad Development Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Supercoiled DNA Binding Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Morphogenesis Of A Branching Structure DNA-binding Transcription Factor Binding Regulation Of Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Reproductive Structure Development DNA Geometric Change Glial Cell Fate Commitment
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