NR5A1 and TRERF1

Number of citations of the paper that reports this interaction (PubMedID 12101186)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NR5A1	TRERF1
Description		nuclear receptor subfamily 5 group A member 1	transcriptional regulating factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Histone Deacetylase Complex Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Enzyme Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Nuclear Progesterone Receptor Binding Metal Ion Binding
	Biological Process	Luteinization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Gene Expression Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Leydig Cell Differentiation Hormone Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Sertoli Cell Differentiation Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Cellular Response To Progesterone Stimulus
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Falling risk ( 32999390) HDL cholesterol levels in HIV infection ( 33109212) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		35 interacting genes: AR CATSPERT CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653	8 interacting genes: CREBBP EP300 ESRRG ITCH KEAP1 NEDD4 NR5A1 YAP1
Entrez ID		2516	55809
HPRD ID		01702	11647
Ensembl ID		ENSG00000136931	ENSG00000124496
Uniprot IDs		F1D8R8 Q13285	A0A8Q3SI57 Q05GC8 Q96PN7
PDB IDs		1YOW 1ZDT 4QJR 4QK4 7KHT 8DAF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Regulation Of Gene Expression Nucleoplasm Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cell Fate Commitment DNA-binding Transcription Factor Binding Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Male Gonad Development Negative Regulation Of Biosynthetic Process Reproductive Structure Development Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity RNA Polymerase II Transcription Regulator Complex Gonad Development Animal Organ Development Pituitary Gland Development Glial Cell Fate Commitment Developmental Induction	Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Radiation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cellular Response To UV Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleus N-terminal Protein Amino Acid Acetylation Cellular Response To Light Stimulus Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Transcription Coregulator Activity Acetyltransferase Activity Chromatin Binding Regulation Of Macromolecule Biosynthetic Process Response To UV Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Response To Radiation Regulation Of Gene Expression Regulation Of Protein Localization To Nucleus Hormone-mediated Signaling Pathway Proline-rich Region Binding Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Innate Immune Response-activating Signaling Pathway DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Activation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Catabolic Process Protein Acetylation Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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