NR5A1 and NFYA

Number of citations of the paper that reports this interaction (PubMedID 12730328)
53

Data Source:
HPRD (in vitro)

		NR5A1	NFYA
Description		nuclear receptor subfamily 5 group A member 1	nuclear transcription factor Y subunit alpha
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Enzyme Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Luteinization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Gene Expression Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Leydig Cell Differentiation Hormone Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Sertoli Cell Differentiation Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)
Interacting Genes		35 interacting genes: AR CATSPERT CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653	50 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 EP300 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TOPBP1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		2516	4800
HPRD ID		01702	01793
Ensembl ID		ENSG00000136931	ENSG00000001167
Uniprot IDs		F1D8R8 Q13285	P23511
PDB IDs		1YOW 1ZDT 4QJR 4QK4 7KHT 8DAF	4AWL 6QMP 6QMQ 6QMS 8QU2 8QU3 8QU4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Regulation Of Gene Expression Nucleoplasm Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cell Fate Commitment DNA-binding Transcription Factor Binding Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Male Gonad Development Negative Regulation Of Biosynthetic Process Reproductive Structure Development Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity RNA Polymerase II Transcription Regulator Complex Gonad Development Animal Organ Development Pituitary Gland Development Glial Cell Fate Commitment Developmental Induction	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Cis-regulatory Region Binding DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Cellular Senescence Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Metabolic Process ER-nucleus Signaling Pathway
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