NR5A1 and TEKT4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NR5A1	TEKT4
Description		nuclear receptor subfamily 5 group A member 1	tektin 4
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Enzyme Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Luteinization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Gene Expression Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Leydig Cell Differentiation Hormone Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Sertoli Cell Differentiation Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Cell Projection Organization Flagellated Sperm Motility Cilium Assembly Cilium Movement Involved In Cell Motility
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Parkinson's disease ( 34064523)
Interacting Genes		35 interacting genes: AR CATSPERT CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653	105 interacting genes: ACBD4 AIRIM AKAP8L ALAS1 AMMECR1 ANKRD55 ARID5A ATG5 BCL6 BLZF1 BORCS8-MEF2B CFAP68 CTDSP1 DDIT4L EFHC2 EYA2 FAM220A GATA1 GPSM1 GRB10 GSE1 HCK HDAC6 HNRNPH1 HNRNPM HOXA1 HOXB5 HOXC8 IKZF3 INCA1 KPRP KRT15 KRT18 KRT34 KRT35 KRT75 KRT86 KRTAP11-1 KRTAP13-1 KRTAP13-3 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP26-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LASP1 LMCD1 LNX1 MAGEA4 MIIP MORN3 MYOZ3 NANOS3 NFKBID NR5A1 PCSK5 PHF11 PKP2 PLAGL2 POLDIP3 PPP1R13B PRDM14 PRDM6 PROP1 PSMA1 PTH1R RAMAC RARA RBM48 RECK RFX6 RUSC1 SAXO4 SCN5A SLC25A6 SMAD3 SOCS4 SPATA8 SPATC1L SPG21 SPMIP6 SUV39H1 TADA2A TEKT1 TFAP4 TOX2 TRIB3 TRIP6 TSPAN4 UBASH3A USP2 VGLL1 ZFP90 ZIM2 ZMYND12 ZNF20 ZNF417 ZNF426 ZNF474 ZNF552 ZNF581 ZNF655 ZNF688
Entrez ID		2516	150483
HPRD ID		01702	14518
Ensembl ID		ENSG00000136931	ENSG00000163060
Uniprot IDs		F1D8R8 Q13285	A0A384MEB7 Q8WW24
PDB IDs		1YOW 1ZDT 4QJR 4QK4 7KHT 8DAF	7UNG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Regulation Of Gene Expression Nucleoplasm Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cell Fate Commitment DNA-binding Transcription Factor Binding Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Male Gonad Development Negative Regulation Of Biosynthetic Process Reproductive Structure Development Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity RNA Polymerase II Transcription Regulator Complex Gonad Development Animal Organ Development Pituitary Gland Development Glial Cell Fate Commitment Developmental Induction	Intermediate Filament Protein Binding Keratin Filament Nucleus Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Axonemal A Tubule Inner Sheath Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Organization Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA Binding Structural Molecule Activity Histone Deacetylase Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Flagellated Sperm Motility Sperm Motility DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cilium-dependent Cell Motility Sperm Flagellum Regulation Of Primary Metabolic Process Cilium Movement Involved In Cell Motility Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Sequence-specific DNA Binding Cilium Movement Negative Regulation Of RNA Metabolic Process Keratinization Erythrocyte Development
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