NR0B1 and EEF2KMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NR0B1	EEF2KMT
Description		nuclear receptor subfamily 0 group B member 1	eukaryotic elongation factor 2 lysine methyltransferase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Ribosome Membrane Nuclear Speck Centriolar Satellite	Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding DNA Hairpin Binding Protein Homodimerization Activity AF-2 Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Developmental Process Involved In Reproduction Spermatogenesis Sex Determination Intracellular Protein Localization Gonad Development Male Gonad Development Negative Regulation Of Steroid Biosynthetic Process Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Endodermal Cell Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of DNA-templated Transcription Sertoli Cell Differentiation	Peptidyl-lysine Trimethylation Methylation
Pathways			Protein methylation
Drugs		Dexamethasone Dexamethasone acetate
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Interacting Genes		17 interacting genes: AR COPS2 EEF2KMT ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1	12 interacting genes: HPRT1 IFT88 KIAA1328 LNX1 NR0B1 PICK1 PRKAR1B PRTFDC1 TRIP13 ZNF213 ZNF35 ZNF620
Entrez ID		190	196483
HPRD ID		08362	18018
Ensembl ID		ENSG00000169297	ENSG00000118894
Uniprot IDs		F1D8P4 P51843	K7ES84 Q96G04
PDB IDs		4RWV	8FZB
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Estrogen Response Element Binding Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Steroid Binding Sequence-specific DNA Binding Nuclear Steroid Receptor Activity DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Lipid Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Response To Lipid Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process DNA Binding Cellular Response To Oxygen-containing Compound Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process	Guanine Salvage Hypoxanthine Phosphoribosyltransferase Activity GMP Catabolic Process Guanine Metabolic Process Purine Ribonucleoside Salvage Purine Nucleobase Biosynthetic Process Nucleoside Salvage Purine Nucleoside Monophosphate Catabolic Process Purine Nucleobase Metabolic Process Purine Nucleoside Metabolic Process GMP Metabolic Process Purine-containing Compound Salvage Nucleoside Metabolic Process Hippocampal Mossy Fiber To CA3 Synapse Ciliary Base DNA Hairpin Binding Guanine Phosphoribosyltransferase Activity Nucleoside Monophosphate Metabolic Process Purine Ribonucleotide Catabolic Process Hypoxanthine Salvage Purine Nucleotide Catabolic Process Adenine Metabolic Process Hypoxanthine Biosynthetic Process Meiotic Recombination Checkpoint Signaling Nucleotide Catabolic Process AF-2 Domain Binding Hypoxanthine Metabolic Process Response To Silicon Dioxide Membrane Curvature Sensor Activity GMP Salvage Nucleoside Phosphate Catabolic Process IMP Salvage Centriolar Satellite Male Gamete Generation Spermatogenesis Positive Regulation Of Dopamine Metabolic Process AMP Salvage Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation CAMP-dependent Protein Kinase Regulator Activity Female Meiosis I Gamete Generation Metal Ion Binding Positive Regulation Of Fear Response Meiotic Cell Cycle Checkpoint Signaling Negative Regulation Of Actin Nucleation
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