ECM1 and IRAK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ECM1	IRAK3
Description		extracellular matrix protein 1	interleukin 1 receptor associated kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protease Binding Interleukin-2 Receptor Binding Extracellular Matrix Structural Constituent Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Ossification Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Chondrocyte Development Regulation Of Type 2 Immune Response Endochondral Bone Growth Regulation Of Transcription By RNA Polymerase II Inflammatory Response Signal Transduction Negative Regulation Of Peptidase Activity Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of T Cell Migration	Positive Regulation Of Cytokine Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Toll Signaling Pathway Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAPK Cascade Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Platelet degranulation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling
Drugs			Fostamatinib
Diseases		Lipoid proteinosis; Urbach-Wiethe disease
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spontaneous coronary artery dissection ( 32374345 32887874) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Response to esketamine in treatment resistant depression ( 32724131) Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		39 interacting genes: A1CF ACTN3 AIRIM ATN1 BCAS2 BNIP3L CPTP CYSRT1 DDIAS DTX2 ENKD1 FASLG FBLN1 FKBP6 FRS3 FXR1 GCM2 GNE GPANK1 GRN HOXC8 HSPG2 IRAK3 ITGB4 KLHL38 KRTAP5-3 KRTAP9-3 LCE2A LIN7A LMO4 MKRN3 PRKAR2B RERE SAMD11 SGTB SNRPC SRPK1 UBQLN1 UBQLN2	17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		1893	11213
HPRD ID		03727	05123
Ensembl ID		ENSG00000143369	ENSG00000090376
Uniprot IDs		A0A140VJI7 Q16610	Q9Y616
PDB IDs			5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?		Embryo Implantation	Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Endosome Membrane Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Toll Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Oxygen-containing Compound Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Immune Response Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Cellular Response To Lipid Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Symbiont
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