NDN and CCDC136

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid, two hybrid)

		NDN	CCDC136
Description		necdin, MAGE family member	coiled-coil domain containing 136
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Protein-containing Complex Cell Projection Perikaryon	Acrosomal Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	DNA Binding Protein Binding Gamma-tubulin Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Respiratory System Process Regulation Of DNA-templated Transcription Axonogenesis Axonal Fasciculation Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Neuron Development Axon Extension Multicellular Organismal-level Homeostasis Genomic Imprinting	Acrosome Assembly Spermatogenesis Single Fertilization Cell Differentiation
Pathways		Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Body size at age 10 ( 32376654) Depressive symptoms (SSRI exposure interaction) ( 25649181) HDL cholesterol levels ( 32203549) Parkinson's disease (age of onset) ( 33884653) Plasma anti-thyroid peroxidase levels ( 29678681) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PALS2 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B	138 interacting genes: ABT1 AQP1 ATP5PO ATXN1 BARD1 BLOC1S6 BYSL C1orf216 C21orf58 CARD9 CBX8 CCDC120 CCDC13 CCDC146 CCDC185 CCDC187 CCDC6 CCHCR1 CDC5L CDK2AP1 CEP57 CEP57L1 CEP95 COIL CWF19L2 DDX6 DISC1 DTNB DYNC1I2 ENKD1 FAM107A FAM161A FAM161B FAM50B FLYWCH1 GFI1B HAUS1 HDAC4 HGS HMG20A HMG20B HOXB5 ISCU JAKMIP2 JMY JRK KANSL1 KAT5 KIF5B KIFC3 LCA5L LENG1 MAGEB4 MBD1 MBD3L2 MCRS1 MOS NDC80 NDN NEBL NEK6 NME7 NOP53 ODAD3 PDLIM5 PIBF1 PKN1 PKN2 POGZ PPP1R18 PRPF18 PRPF3 PRPF31 PRR35 PSMA1 PSMC5 PSMD9 RAB33A RAB33B RALBP1 RASAL3 RASSF8 SCNM1 SDHAF1 SHFL SMARCA2 SMARCE1 SYT6 TBRG1 TCEA2 TCEANC THAP7 TNNT1 TRAF3IP3 TSGA10 TSGA10IP TSPYL1 TXLNA UBQLN4 UBTFL1 USP2 WT1 ZBTB24 ZBTB38 ZBTB47 ZC2HC1C ZFP1 ZFYVE26 ZNF124 ZNF20 ZNF223 ZNF230 ZNF250 ZNF264 ZNF329 ZNF35 ZNF408 ZNF417 ZNF440 ZNF490 ZNF497 ZNF564 ZNF572 ZNF580 ZNF581 ZNF587 ZNF599 ZNF648 ZNF669 ZNF670 ZNF688 ZNF696 ZNF774 ZNF777 ZNF785 ZNF835 ZNF837 ZSCAN26
Entrez ID		4692	64753
HPRD ID		03667	10887
Ensembl ID		ENSG00000182636	ENSG00000128596
Uniprot IDs		Q99608 X5D982	C9JU31 Q96JN2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cis-regulatory Region Sequence-specific DNA Binding Axo-dendritic Transport Circadian Rhythm Transport Along Microtubule Cellular Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Neuron Apoptotic Process Cytoskeleton-dependent Intracellular Transport Axon Cytoplasm Microtubule-based Transport Axonal Transport Circadian Regulation Of Gene Expression Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Cytoplasm Cellular Response To Decreased Oxygen Levels DNA-binding Transcription Activator Activity Promoter-specific Chromatin Binding Embryonic Placenta Development Cellular Homeostasis Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Rhythmic Process Cellular Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Chemical Homeostasis Organelle Transport Along Microtubule Intracellular Glucose Homeostasis Regulation Of Fibroblast Proliferation Positive Regulation Of Biosynthetic Process Stress-induced Premature Senescence Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex MRNA Metabolic Process PML Body Anterograde Axonal Transport Nuclear Receptor Binding Connective Tissue Replacement Microtubule-based Process Intracellular Oxygen Homeostasis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Protein Domain Specific Binding	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Centrosome Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding Regulation Of Metabolic Process Cytoskeleton Chromatin Organization Microtubule-based Process Cilium Organization Nuclear Speck Microtubule Binding Spindle Pole Organelle Assembly Nuclear Proteasome Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding Nucleoplasm Regulation Of Sister Chromatid Segregation Cellular Component Assembly Microtubule Cytoskeleton Organization DNA-binding Transcription Factor Activity Centriole Protein Localization To Nucleoplasm Establishment Of Spindle Orientation Microtubule Double-stranded Methylated DNA Binding Cytosolic Proteasome Complex Centriolar Satellite Regulation Of Chromosome Segregation Regulation Of Protein Sumoylation Non-motile Cilium Assembly Histone Acetyltransferase Complex Ciliary Basal Body Establishment Of Spindle Localization
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