NDN and NEFL

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		NDN	NEFL
Gene Name		necdin, melanoma antigen (MAGE) family member	neurofilament, light polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Cell Projection Perikaryon	Cytoplasm Cytosol Neurofilament Axon Growth Cone TSC1-TSC2 Complex
	Molecular Function	DNA Binding Gamma-tubulin Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Phospholipase Binding
	Biological Process	Neuron Migration Respiratory System Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Axonal Fasciculation Central Nervous System Development Negative Regulation Of Cell Proliferation Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Axon Extension Multicellular Organismal Homeostasis Genetic Imprinting	Microtubule Cytoskeleton Organization Synaptic Transmission Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axon Transport Of Mitochondrion Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: APBB1IP ARSE BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 LAX1 LPXN MIER2 MKRN2 MPP6 N6AMT2 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PJA1 PPFIA1 SERTAD3 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B	29 interactors: BRD7 CCNC CDK5RAP2 CHD3 ENKD1 GRIN1 KDM1A KIFC3 KRT15 MAP2 MTMR2 MYO5A NDN NEFH NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SPTAN1 TERF1 TEX11 TSC1 TXLNB USP2 VIM YWHAG
Entrez ID		4692	4747
HPRD ID		03667	01206
Ensembl ID		ENSG00000182636
Uniprot IDs		Q99608	P07196
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Anterograde Axon Cargo Transport Regulation Of Fibroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels RNA Metabolic Process Cellular Response To Oxygen Levels Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Gene Expression Response To Wounding Regulation Of Gene Expression Transcription, DNA-templated Microtubule-based Movement RNA Biosynthetic Process Cellular Localization Positive Regulation Of Fibroblast Proliferation Circadian Rhythm MRNA Transcription From RNA Polymerase II Promoter Cell Differentiation Wound Healing Regulation Of Thymocyte Apoptotic Process MRNA Transcription Transcription From RNA Polymerase II Promoter Developmental Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Anterograde Synaptic Vesicle Transport Regulation Of Establishment Of Protein Localization Establishment Of Localization In Cell Positive Regulation Of Natural Killer Cell Activation Melanosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Pigment Granule Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Embryonic Placenta Development Regulation Of Cellular Localization Tissue Remodeling Iron Ion Homeostasis MRNA Stabilization Cell Morphogenesis Microtubule-based Process Anatomical Structure Development	Nervous System Development Developmental Process Anatomical Structure Development Regulation Of Cellular Component Organization System Development Central Nervous System Development Organelle Organization Cell Differentiation Cell Projection Organization Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Neurogenesis Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Cell Cycle Cell Development Movement Of Cell Or Subcellular Component Microtubule-based Process Intermediate Filament Organization Axonogenesis Regulation Of Cellular Process Response To Stimulus G2/M Transition Of Mitotic Cell Cycle Axon Development Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Cycle Cellular Component Maintenance Chromatin Modification Negative Regulation Of Biosynthetic Process Neuron Development Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Morphogenesis Myelination Axon Ensheathment Chromosome Organization Cell Cycle Process Regulation Of Gene Expression Regulation Of Microtubule-based Process Chromatin Organization Cell Morphogenesis Involved In Differentiation Intermediate Filament Cytoskeleton Organization Neuron Differentiation Intermediate Filament-based Process Protein Oligomerization Microtubule Bundle Formation Microtubule Cytoskeleton Organization Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Tagcloud ?		biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?