NDN and IL1A

Number of citations of the paper that reports this interaction (PMID 12913118)
15

Data Source:
HPRD (in vitro, two hybrid)

		NDN	IL1A
Gene Name		necdin, melanoma antigen (MAGE) family member	interleukin 1, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Cell Projection Perikaryon	Extracellular Region Extracellular Space Cytosol
	Molecular Function	DNA Binding Gamma-tubulin Binding	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Neuron Migration Respiratory System Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Axonal Fasciculation Central Nervous System Development Negative Regulation Of Cell Proliferation Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Axon Extension Multicellular Organismal Homeostasis Genetic Imprinting	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Apoptotic Process Inflammatory Response Immune Response Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Response To Copper Ion Positive Regulation Of Cytokine Secretion Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by Interleukins Interleukin-1 processing Cellular Senescence Interleukin-1 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Endometriosis ( 20844546) Working memory ( 21107309)
Protein-Protein Interactions		43 interactors: APBB1IP ARSE BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 LAX1 LPXN MIER2 MKRN2 MPP6 N6AMT2 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PJA1 PPFIA1 SERTAD3 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B	9 interactors: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP NDN NFKBIE S100A13
Entrez ID		4692	3552
HPRD ID		03667	00988
Ensembl ID		ENSG00000182636
Uniprot IDs		Q99608	P01583
PDB IDs			1ITA 2ILA 2KKI 2L5X
Enriched GO Terms of Interacting Partners?		Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Anterograde Axon Cargo Transport Regulation Of Fibroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels RNA Metabolic Process Cellular Response To Oxygen Levels Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Gene Expression Response To Wounding Regulation Of Gene Expression Transcription, DNA-templated Microtubule-based Movement RNA Biosynthetic Process Cellular Localization Positive Regulation Of Fibroblast Proliferation Circadian Rhythm MRNA Transcription From RNA Polymerase II Promoter Cell Differentiation Wound Healing Regulation Of Thymocyte Apoptotic Process MRNA Transcription Transcription From RNA Polymerase II Promoter Developmental Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Anterograde Synaptic Vesicle Transport Regulation Of Establishment Of Protein Localization Establishment Of Localization In Cell Positive Regulation Of Natural Killer Cell Activation Melanosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Pigment Granule Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Embryonic Placenta Development Regulation Of Cellular Localization Tissue Remodeling Iron Ion Homeostasis MRNA Stabilization Cell Morphogenesis Microtubule-based Process Anatomical Structure Development	Cytokine Production Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Immune Response Response To Cytokine Response To Organic Substance Interleukin-1 Alpha Secretion Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Autophagy D-serine Transport Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Interleukin-2 Biosynthetic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Interleukin-1 Secretion Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Interleukin-2 Production Positive Regulation Of Granulocyte Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitochondrion Degradation Regulation Of Intracellular Protein Transport Interleukin-1-mediated Signaling Pathway Regulation Of Inflammatory Response Interleukin-1 Beta Production Receptor Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Actin Cytoskeleton Reorganization Respiratory System Process Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Cytokine Biosynthetic Process Response To Copper Ion Regulation Of Interleukin-1 Beta Secretion Axonal Fasciculation Cytoplasmic Sequestering Of Protein Positive Regulation Of Signal Transduction Response To Stimulus Mast Cell Degranulation
Tagcloud ?		biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1	45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il1b il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter
Tagcloud (Difference) ?		biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1	45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il1b il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter
Tagcloud (Intersection) ?